The role of selective and novel biomarkers and their correlation with clinical outcome measures, pre and post-surgical treatment of benign and malignant disorders of the prostate


   PhD Opportunities

  ,  Applications accepted all year round  Self-Funded PhD Students Only

About the Project

The Maelor Academic Unit of Medical & Surgical Sciences (MAUMSS) is a novel initiative by the Betsi Cadwaladr University Health Board (BCUHB), and is designed to encourage and support research within the Health Board and to promote academic activity, basic science and clinical research across North Wales (UK) and beyond. MAUMSS is located in Wrexham (North Wales, UK) and staffed by an interdisciplinary team of academics, clinicians, scientists and postgraduate students who are available to lead on and help other healthcare professionals develop and run all kinds of clinical research projects. It has several laboratories containing state-of-the-art molecular, analytical and diagnostic equipment. There are also meeting rooms, video-conferencing and hot-desk facilities too. All of this is available for use to encourage new researchers (promote lifelong learning and continuous professional development), help maximise research impact and ultimately provide better outcomes for patients and the public.

As part of its formal collaborative partnership with Wrexham Glyndwr University (WGU), MAUMSS has been instrumental in conceiving, developing and subsequently delivering an Institute of Biomedical Science (IBMS) accredited BSc (Hons) Biomedical Science, an MSc Biomedical Science and two IBMS approved MRes programmes in Applied Biomedical Sciences Research and Applied Clinical Research. MAUMSS, in collaboration with WGU, also deliver successful MPhil and PhD (including Professional Doctorates) programmes. To date, these academic programmes have been very successful and continue to grow and have provided the opportunity for the development of new academic programmes, which further strengthens the well-established collaborative partnership between BUCHB and WGU.

PhD Project

Background:

The number of patients in the UK having surgical interventions for the treatment of benign and malignant disorders of the prostate is increasing annually. As such, there have been an increasing number of patients developing disease recurrence and progression, as well as post-operative complications (e.g. infection and blood clots).​

Post-operative complications result in patients requiring longer hospital stays, poor patient experience and outcomes, as well as carrying additional financial constraints for the healthcare provider (NHS). Minor improvements in the monitoring of these patients following treatment could possibly have financial benefits for the healthcare provider and health benefits for the nation.

Aims:

Specifically, the proposed study will aim to investigate the role of selective and novel biomarkers and their correlation with clinical outcome measures, pre and post-surgical treatment of benign and malignant disorders of the prostate.

As part of your PhD you will be registered with Wrexham Glyndwr University (Wrexham, North Wales, UK) and based at BCUHB-MAUMSS.

NB: A small contribution toward tuition fees of up to £1500 per year may be provided for this study.

Biological Sciences (4) Medicine (26)

Funding Notes

Applications from UK/European and International Students (worldwide) are welcome.
Prospective students will be eligible to enrol for a PhD via Wrexham Glyndwr University or Staffordshire University. MAUMSS are formally affiliated with both these HE institutions.

References

Some recent papers published from our group:
Ella-Tongwiis, P., Makanga, A., Shergill, I., & Fôn Hughes, S. (2021). Optimisation and validation of immunohistochemistry protocols for cancer research. Histology and histopathology, 36(4), 415–424. https://doi.org/10.14670/HH-18-317
Hughes SF, Moyes AJ, Lamb RM, Ella-Tongwiis P, Snyper NYF, Shergill I (2020). The role of phagocytic leukocytes following flexible ureterenoscopy, for the treatment of kidney stones: an observational, clinical pilots-study. Eur J Med Res. 2020 Dec 11;25(1):68. doi: 10.1186/s40001-020-00466-7. PMID: 33308282; PMCID: PMC7731777.
Hughes S.F., Lamb R.M., Moyes, A.J., Ella-tongwiis, P., Gill, A., Duckett, A., & Shergill, I. (2020). The Effect of Trans-urethral Resection of the Bladder Tumour (TURBT) on Routine Haematological and Biochemical Blood Tests: A Clinical-pilot Observational Study. Int J Biomed Sci, December 2020 Vol. 16 No. 4.

Register your interest for this project