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Loughborough University Featured PhD Programmes

The role of syndecan-4 as a regulator of the tumour microenvironment in pancreatic cancer


School of Medicine

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Dr Stephen Thorpe No more applications being accepted Funded PhD Project (Students Worldwide)

About the Project

This research project will assess the role of syndecan-4 in pancreatic cancer progression. Despite its relatively low prevalence, pancreatic cancer is the 5th leading cause of cancer-related mortality and will claim approx. 130,000 European lives this year. Syndecan-4 is a cell surface adhesion receptor and biophysical forces acting on syndecan-4 are converted into a cell-stiffening response involving cell-wide activation of matrix connections. This provides a potential mechanism through which stromal cells remodel the tumour microenvironment. Targeting this pathway may provide a route to facilitate treatment and prevent metastasis. This interdisciplinary PhD project will assess the role of syndecan-4 in matrix remodelling and cancer progression using in vitro and in vivo pancreatic cancer models alongside primary tumour tissue. This project provides the opportunity to acquire expertise in a wide range of cutting-edge cell and molecular biological techniques and biophysical characterisation. Experience in any of the following areas is desirable: bioengineering, biomedical science, 3D cell/organoid culture, in vivo mouse models, CRISPR, and/or atomic force microscopy.

For further information and to apply, please contact:
Dr Stephen Thorpe
Email: [Email Address Removed]
https://people.ucd.ie/stephen.thorpe
UCD Ad Astra PhD Studentships
The UCD School of Medicine & School of Veterinary Medicine, University College Dublin, Ireland, is pleased to announce ten generously funded PhD studentships which will be supervised by our recently appointed Ad Astra Fellows. Students will be enrolled onto UCD’s structured PhD programme which includes some taught elements and transferrable skills training providing an excellent foundation for a research career. https://www.ucd.ie/graduatestudies/researchprogrammes/structuredphd/

The studentships are open to EU and non-EU candidates and are for a maximum of four years, renewable each year, subject to satisfactory progress.
Applicant Requirements
Applicants must have, or expect to have, reached a minimum of an upper second-class (2.1) degree or equivalent in a relevant honours Bachelor’s or Master’s degree. Excellent written and oral communication skills and a high level of competence in the English language are essential.

http://www.ucd.ie/registry/admissions/elr.html
Application Details
Applicants should submit the following to the supervisor of the relevant project as a single .pdf document:

1. A cover letter outlining their interest in the project and any relevant experience
2. A detailed CV (including a list of any publications if applicable)
3. The names and contact details of two academic referees

Interviews will take place via video call in July.

Funding Notes

The studentship award includes full tuition fee waiver, a PhD stipend of €18,000 per annum, and a research budget to cover research costs associated with the project.


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