Coventry University Featured PhD Programmes
University of Leeds Featured PhD Programmes
Cardiff University Featured PhD Programmes

The role of tetraspanin proteins in the regulation of the tumour microenvironment.


Institute of Cancer and Genomic Sciences

Applications accepted all year round Self-Funded PhD Students Only

About the Project

The immune cell landscape within tumour microenvironment is controlled by an elaborate network of communications involving chemokines, cytokines and growth factors which are produced by tumour-infiltrating immune cells themselves, by cancer cells and by other cell types in cancerous tissues (e.g. tumour endothelium, tumour-associated fibroblasts). Four transmembrane domain proteins of the tetraspanin superfamily have recently emerged as important regulators of tumour microenvironment by regulating the activity of matrix metalloproteases which facilitate release of surface-associated chemokines, cytokines and growth factors and reorganise the extracellular matrix (ECM). Tetraspanins may also act via exosomes, small secreted nanovesicles, which facilitate both short- and long-range communications between various cell types. In this regard, tetraspanins are abundant on exosomes and changes in tetraspanin expression have an impact on the protein composition of exosomes. We have demonstrated that the expression of various tetraspanin proteins is dysregulated in breast cancers and this correlated with variations in the profile of immune cells that are recruited to the cancerous tissues. Currently we are focused on identifying molecular networks underlying tetraspanin-dependent changes in the immune microenvironment in breast and colorectal cancers.

Funding Notes

We consider only self-funded/government-funded applicants

References

1. Hayward S, Gachehiladze M, Badr N, Andrijes R, Molostvov G, Paniushkina L, Sopikova B, Slobodová Z, Mgebrishvili G, Sharma N, Horimoto Y, Burg D, Robertson G, Hanby A, Hoar F, Rea D, Eckhardt BL, Ueno NT, Nazarenko I, Long HM, van Laere S, Shaaban AM, Berditchevski F. The CD151-midkine Pathway Regulates the Immune Microenvironment in Inflammatory Breast Cancer. 2020, J Pathol. 251: 63-73.
2. Badr NM, Berditchevski F, Shaaban AM. The Immune Microenvironment in Breast Carcinoma: Predictive and Prognostic Role in the Neoadjuvant Setting, 2020, Pathobiology, 87: 61-74.

Email Now

Insert previous message below for editing? 
You haven’t included a message. Providing a specific message means universities will take your enquiry more seriously and helps them provide the information you need.
Why not add a message here

The information you submit to University of Birmingham will only be used by them or their data partners to deal with your enquiry, according to their privacy notice. For more information on how we use and store your data, please read our privacy statement.

* required field

Your enquiry has been emailed successfully



Search Suggestions

Search Suggestions

Based on your current searches we recommend the following search filters.



FindAPhD. Copyright 2005-2020
All rights reserved.