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The role of ZAP in defence against human cytomegalovirus

Project Description

Determining the function of cellular anti-viral factors is now at the forefront of virology and immunobiology because these
factors are now known to shape how viruses interact with human populations.

In this multi-institution project, we examine the role of zinc finger anti-viral protein (ZAP), whose function has only recently been described, in virus-host interaction with human populations. We aim to examine how mutations in ZAP found in human populations affect ZAP function and how this relates to defence against viral infection. In these experiments we will study ZAP interaction with human cytomegalovirus (HCMV), a major human pathogen found worldwide whose widespread prevalence in humans is not well understood.

The student will acquire and develop expertise in the study of a global human pathogen, virus-host interactions and genomics. This will include development of laboratory skills in biochemistry, molecular and cellular biology, viral immunobiology and genetic analysis. All of these skill sets will allow the student to pursue career paths in infection and immunity research and beyond. Moreover, this project has elements of transferable skills (for example project management across different institutions) that can applied to numerous career paths outside of laboratory research.

Potential applicants are strongly encouraged to contact the supervisors to discuss project details.

The current studentship is part of the MRC London Intercollegiate Doctoral Training Partnership (MRC-LID) between The London School of Hygiene and Tropical Medicine (LSHTM) and St. George’s University of London (SGUL)

Subsequently applications can be made by following the instructions on the MRC-LID site at

Please click on the following link for more information about the MRC-LID programme:

For more information on funding please go to:

The deadline for applications is Wednesday 1 January 2020.

Funding Notes

To be eligible for a full studentship award applicants must
(a) hold, or expect to obtain before September 2020, a 1st or 2.1 Honours degree (as a minimum), and
(b) be a UK or EU citizen, and
(c) have maintained ordinary residence in the UK continuously for the 3 years preceding 1 September 2020.

To be generally eligible for a fees-only studentship award applicants must
(a) hold, or expect to obtain before September 2020, a 1st or 2.1 Honours degree (as a minimum), and
(b) be a UK or EU citizen.

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