White Rose BBSRC Doctoral Training Partnership in Mechanistic Biology
4 year fully-funded programme of integrated research and skills training, starting Oct 2019:
• Research Council Stipend
• UK/EU Tuition Fees
• Conference allowance
• Research Costs
At least a 2:1 honours degree or equivalent. We welcome students with backgrounds in biological, chemical or physical sciences, or mathematical backgrounds with an interest in biological questions.
EU candidates require 3 years of UK residency in order to receive full studentship
Not all projects advertised will be funded; the DTP will appoint a limited number of candidates via a competitive process.
Patel, N.*, White, S.J.*, Thompson, R.F., Weiß, E.U.1, Bingham, R.1, Zlotnick, A.2, Dykeman, E.1, Twarock, R.,1‡ Ranson, N.A.‡ & Stockley, P.G.‡ (2017). The HBV RNA pregenome encodes specific interactions with the viral core protein that can promote nucleocapsid assembly. Nature Microbiology, DOI:10.1038/nmicrobiol.2017.98
Iadanza, M.G*., Higgins, A.J.*, Schiffrin, R., Calabrese, A., Brockwell, D.J., Ashcroft, A.E. Radford, S.E. ‡ & Ranson, N.A.‡ (2016). Lateral opening of the intact β-barrel assembly machinery captured by cryo-EM Nature Comms. DOI:10.1038/ncomms12865.
Hesketh, E.L., Meshcheriakova, Y., Dent, K.C., Saxena, P., Thompson, R.F., Cockburn, J.J.B, Lomonossoff, G.P. & Ranson, N.A. (2015). Mechanisms of assembly and genome packaging in an RNA virus revealed by high-resolution cryo-EM. Nature Comms., DOI:10.1038/ncomms10113
Goodchild, S.C., Sheynis, T., Thompson, R., Tipping, K.W., Xue, W.F., Ranson, N.A., Beales, P.A., Hewitt, E.W. & Radford, S.E. (2014). β2-Microglobulin Amyloid Fibril-Induced Membrane Disruption Is Enhanced by Endosomal Lipids and Acidic pH. PLoS One, 9 (8), e104492
Skp is a multivalent chaperone of outer membrane proteins. Schiffrin, R., Calabrese, A.N., Devine, P.W.A., Harris, S.A., Ashcroft, A.E., Brockwell. D.J. & Radford, S.E. (2016) Nat. Struct. Mol. Biol. in press
FPOP-LC-MS/MS suggests differences in interaction sites of amphipols and detergents with outer membrane proteins. Watkinson, T.G., Calabrese, A.N., Ault, J,R., Radford, S.E. & Ashcroft, A.E. (2016) J. Am. Soc. Mass Spectrom., in press
Two-way communication between SecY and SecA suggests a Brownian ratchet mechanism for protein translocation. Allen, W.J., Corey, R.A., Oatley, P., Sessions, R.B., Baldwin, S.A., Radford, S.E., Tuma, R. & Collinson, I. (2016) Elife, 5, e15598
Substrate protein folds while it is bound to the ATP-independent chaperone Spy. Stull, F., Koldewey, P., Humes, J.R., Radford, S.E. & Bardwell, J.C.A. (2016) Nat. Struct. Mol. Biol. 1, 53-59
FTE Category A staff submitted: 60.90
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