The ubiquitin proteasome system and neurodegenerative disease
The mechanisms that cause neurones to die in neurodegenerative diseases such as Alzheimer’s and Parkinson’s diseases remain unclear. The ubiquitin proteasome system is essential for the degradation of unwanted intracellular proteins. We are using a unique in vivo genetic mammalian model of 26S proteasome dysfunction in neurones to investigate mechanisms involved in neurodegeneration. The early stages of neurodegeneration are thought to involve progressive protein and functional changes in synapses, before neuronal death. Synapses are essential to neuronal function – they are the means by which neurones in the brain communicate. In this project we wish to investigate the protein changes in synaptosomes during progressive neurodegeneration following 26S proteasome dysfunction. Our work will identify mechanisms associated with disease progression and therefore highlight potential avenues for therapeutic intervention in human disease.
The University of Nottingham is one of the world’s most respected research-intensive universities, ranked 8th in the UK for research power (REF 2014). Students studying in the School of Life Sciences will have the opportunity to thrive in a vibrant, multidisciplinary environment, with expert supervision from leaders in their field, state-of-the-art facilities and strong links with industry. Students are closely monitored in terms of their personal and professional progression throughout their study period and are assigned academic mentors in addition to their supervisory team. The School provides structured training as a fundamental part of postgraduate personal development and our training programme enables students to develop skills across the four domains of the Vitae Researcher Development Framework (RDF). During their studies, students will also have the opportunity to attend and present at conferences around the world. The School puts strong emphasis on the promotion of postgraduate research with a 2-day annual PhD research symposium attended by all students, plus academic staff and invited speakers.
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How good is research at University of Nottingham in Biological Sciences?
FTE Category A staff submitted: 90.86
Research output data provided by the Research Excellence Framework (REF)
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