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  The use of mass spectrometry-based proteomics to understand drug metabolism in polycystic kidney disease


   Faculty of Biology, Medicine and Health

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  Dr J Barber, Prof A Rostami  No more applications being accepted  Funded PhD Project (Students Worldwide)

About the Project

The project to be undertaken at the University of Manchester, involves the use of mass spectrometry-based proteomics to understand the metabolism and transport of drugs in polycystic kidney disease with a view to optimising drug doses and potentially identifying novel drug targets in these patients. Samples will be collected from a mouse model of polycystic kidney disease and from cell cultures derived from human patients in two short spells working in the Netherlands as part of the DrugTrain consortium on polycystic kidney disease. In Manchester, these samples will be analysed and the data used to build an in silico model of drug metabolism in polycystic kidney disease

Full details including eligibility can be found on: The University of Manchester | Jobs | Search here for your perfect career and candidates should apply through this advertisement.

As an equal opportunities employer we welcome applicants from all sections of the community regardless of age, sex, gender (or gender identity), ethnicity, disability, sexual orientation and transgender status. All appointments are made on merit.


References

Mass Spectrometry-Based Abundance Atlas of ABC Transporters in Human Liver, Gut, Kidney, Brain, and Skin
ZM Al-Majdoub, B Achour, N Couto, M Howard, Y Elmorsi, D Scotcher, S Alrubia, E El-Khateeb, A-M Vasilogianni, S Neuhoff, L Schmidt, A Rostami-Hodjegan, J Barber, FEBS Letts 2020, doi.org/10.1002/1873-3468.13982
Quantitative proteomics of clinically relevant drug-metabolizing enzymes and drug transporters and their intercorrelations in the human small intestine
N Couto, ZM Al-Majdoub, S Gibson, PJ Davies, B Achour, MD Harwood, G Carson, J Barber, A Rostami-Hodjegan, G Warhurst. Drug Metab. Dispos. 2020, 48: 245-254.
Characterization of CYP2B6 K262R allelic variants by quantitative allele-specific proteomics using a QconCAT standard
J Barber, MR Russell, A Rostami-Hodjegan, B Achour. J Pharm. Biomed. Analysis 2020, 178, 112901.

 About the Project