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TheraCav: Harnessing Cavitation for Therapy

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  • Full or part time
    Dr Paul Prentice
  • Application Deadline
    Applications accepted all year round
  • Funded PhD Project (European/UK Students Only)
    Funded PhD Project (European/UK Students Only)

Project Description

'TheraCav' (Harnessing Cavitation for Therapy; PI Dr Paul Prentice, CoI: Prof Sandy Cochran) is an ambitious and generously funded European Research Council project, that seeks to redefine the mechanism of Focused Ultrasound Surgery from the current thermal ablation, to one harnessing acoustic cavitation for tissue permeabilisation and targeted drug delivery.

Acoustic cavitation is an extremely rapid and mechanical phenomenon, currently regarded as stochastic and uncontrollable. TheraCav will investigate the fundamental and ultra-fast physics underpinning cavitation nucleation and evolution [1, 2], translating the significant therapeutic potential toward clinical practice, with particular emphasis on Focused Ultrasound Surgery of the Brain [3]. Ultra-sensitive acoustic detection, cavitation-control device and strategy development, will be combined with fundamental observations via state-of-the-art ultra-high speed micro-photography. Preclinical translational aspects include assessment of bio-effects in tissue and tissue models, and anatomical device verification.

Two 42 month PhD studentships are available, suitable for candidates with backgrounds ranging from applied physics through to biomedical engineering. The positions would suit highly motivated individuals, keen to work at the interface between disciplines.

The stipend is £13,885 p.a.


For further details and general enquiries, please contact Dr Paul Prentice ([Email Address Removed])

Funding Notes

European Research Council (ERC)

References


[1] Gerold et al Review of Scientific Instruments 82(4) 044902 (2011)

[2] Gerold et al New Journal of Physics 15 033044 (2013)

[3] Elais et al New England Journal of Medicine 369 640-8 (2013)



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