Therapeutic modulation of radioiodine uptake in thyroid and breast cancer


   Institute of Metabolism and Systems Research

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  Dr C McCabe  Applications accepted all year round  Self-Funded PhD Students Only

About the Project

We are seeking talented, motivated students with a passion for research in thyroid or breast cancer led by Professor Chris McCabe at the University of Birmingham (Professor Chris McCabe - Institute of Metabolism and Systems Research - University of Birmingham).

Applicants should have a first or upper second-class degree in a relevant scientific discipline, and who are self-funded or have secured funding for their studies from their government, employer or associated charitable organisations, which covers all costs including bench fees.

We are currently prioritising research focussed on the following areas:

• Aetiological mechanisms of endocrine cancers, including thyroid and breast tumour models.

• The actions of the sodium iodide symporter NIS in thyroid and breast tumours.

• Iterative drug design in cellular and murine models of thyroid and breast cancer.

• Therapeutic modulation of radioiodine uptake in vitro and in vivo.

The future plan of the group is to move towards more defined translational models of NIS function, pioneered through joined up national and international collaborative research ventures. Thus the future ambition is to unite disparate themes in improving the central therapy of radioiodine treatment for thyroid cancer, and to develop the potential for its use in breast cancer.

Biological Sciences (4) Medicine (26)

Funding Notes

Applicants are invited from self-funded or scholarship-funded graduates ONLY.

Applicants will be self-funded or will have typically applied for, or secured funding for their studies from their government, employer or associated charitable organisations.

References

Read ML, Brookes K, Thornton C, Fletcher AL, Alshahrani M, Khan R, Nieto H, de Souza PB, Webster JRM, Alderwick LJ, Boelaert K, Smith VE, McCabe CJ. 2022. New mechanisms of radioiodide uptake revealed via a novel high throughput drug screening approach in thyroid cancer. Cell Chem Biol 29(3):502-516

Nieto HR, Thornton CEM, Brookes K, de Menezes AN, Fletcher A, Alshahrani M, Kocbiyik M, Sharma N, Boelaert K, Cazier JB, Mehanna H, Smith VE, Read ML, McCabe CJ. 2022. Recurrence of Papillary Thyroid Cancer: A Systematic Appraisal of Risk Factors. JCEM 107(5):1392-1406; Highlighted Article, 2022

Fletcher A., Read M.L., Thornton C.E.M., Larner D.P., Poole V.L., Brookes K., Nieto H.R., Alshahrani M., Thompson R.J., Lavery G.G., Landa I., Fagin J.A., Campbell M.J., Boelaert K., Turnell A.S., Smith V.E. and McCabe C.J. 2020. Strategically targeting novel sodium iodide symporter interactors to enhance radioiodine uptake. Cancer Research 80(1):102-115

Where will I study?

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