About the Project
Current drug discovery attempts for Covid-19 have severely been hampered due to the lack of cell-free and live virus free high-throughput assay systems. To overcome these limitations, in silico drug screening targeting viral and human ACE2 receptor proteins and structure and network-based design against specific viral proteins have been initiated. However, these approaches suffer from numerous intrinsic variables including obtaining three dimensional structure of the target proteins, lack of reliable docking and soring systems and moreover, they require further extensive experimental validation.
We have previously developed high-throughput splicing assays, screened thousands of natural products and established drugs and identified novel hits for a number of disorders including pulmonary arterial hypertension (PAH) and myelodysplastic syndrome (MDS). The major objectives of this project are (i) develop high-throughput assay systems and screen natural products, (ii) investigate the molecular mechanisms by which the viral proteins may contribute to disease pathogenesis, and (iii) determine whether natural products may provide therapeutic intervention.
The project will introduce the student to the broader areas of molecular genetics, biochemistry, drug discovery, pharmacology and translational medicine. The research activities will be undertaken at the School of Pharmacy and Medical Sciences, University of Bradford. The studies will be performed in the recently renovated laboratories provided with state of the art equipments including high-throughput fluorescence and luminescence plate readers, QPCR machines, gel doc systems and modern tissue culture facilities. The research sits in the context of a highly active research environment at the University of Bradford.
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