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Three Dimensional Wall-less Microtitre Plates

   School of Chemistry

   Applications accepted all year round  Self-Funded PhD Students Only

About the Project

High-throughput assays allow cost-effective testing of large libraries of bio/chemical molecules for drug discovery, disease diagnosis, and industrial biotechnology. High-throughput assays are currently performed using microtitre plates, but throughput of assays can be significantly increased by levitation and manipulation of sample/reagent droplets in mid-air in three dimensional space. Equally, droplets levitated in mid-air are not in contact with any walls, and this wall-less operation offers an ultraclean environment, eliminating loss of sample/regents by adsorption to walls. Finally, such three dimensional wall-less microtitre plates can reduce lab plastic waste.

The realisation of the three dimensional wall-less microtitre plates in turn requires high throughput generation of droplets of samples and reagents. This project will investigate and develop methods for generation of required number of droplets at the desired speed. A combination of experiments and finite element modelling will be used in this project. The student will be based in the Gupta group ( in the School of Chemistry at the University of Birmingham. The project will benefit from the close collaborations that the School of Chemistry has with Schools of Mathematics, Physics, and Computer Sciences.

Applications from self-funded students are invited. No scholarships are available for this project. Interested candidates may contact Dr Gupta () for an informal discussion.

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