Thyroid hormones are key endogenous regulators of heart rate and contractility. Low levels of thyroid hormones in the blood result in a slow heart rate and reduced contractility and this is evident in hypothyroidism. High heart rate and increased myocardial contractility is typical of hyperthyroidism. Thyroid disease and abnormalities in blood thyroid hormone levels have long been known to increase the risk of developing cardiovascular disease (e.g., hypertension, myocardial infarction/heart attack, stroke, atrial fibrillation); however, significant knowledge gaps exist concerning the precise molecular and biochemical mechanisms governing thyroid hormone effects on the heart. Knowledge of such underlying mechanisms is crucial for the management of abnormalities in thyroid function in patients with and without pre-existing heart disease. This PhD project proposes to investigate and elucidate key molecular and biochemical mechanisms governing thyroid hormone action on heart rate and the cardiac tissue responsible for the heart rate, the sinoatrial node.
We have an ongoing programme of research involving laboratory-based pre-clinical and clinical projects investigating links between thyroid hormones and cardiovascular disease. Previous work from our group has demonstrated that reducing blood levels of thyroid hormones lowers heart rate and with pronounced changes in expression of key pacemaker genes in the sinoatrial node. This PhD project will build on our prior work and using a combination of electrophysiology and tissue culture models aim to identify the direct (i.e., nongenomic) and genomic effects of thyroid hormones on sinoatrial node function, structure and associated protein and gene expression. The project will provide a comprehensive training for a PhD student in a range of widely applicable conventional laboratory techniques as well as cutting-edge approaches (e.g., electrophysiology, primary tissue culture, quantitative PCR, Western blot/immunohistochemistry, -omics).
We are looking for a highly motivated student who is willing to pursue cutting edge research within a vibrant and collegiate team. The PhD candidate will be based in the Department of Cardiovascular and Metabolic Medicine, University of Liverpool. The position would suit candidates with a background in cardiovascular/endocrine science. Candidates with good communication skills and experience in one or more of the laboratory methods: electrophysiology, biochemistry and/or molecular biology are encouraged to apply. A BSc/MSc/MRes in biology/biomedical sciences, physiology, pharmacology, endocrinology, or a health-related subject would be essential.
Furthermore, all postgraduate students undertake the Post Graduate Researcher (PGR) Development Programme which aims to enhance their skills for a successful research experience and career. They are required to maintain an online record of their progress and record their personal and professional development throughout their research degree. The Liverpool Centre for Cardiovascular Science holds monthly research group meetings where students are given opportunities to present their research and meet and interact with their peers and senior researchers. Students are also encouraged to attend the seminar series to gain a breadth of knowledge from related research within the Department of Cardiovascular and Metabolic Medicine and wider research themes across our Institute.
The Institute of Life Course and Medical Science is fully committed to promoting gender equality in all activities. In recruitment we emphasize the supportive nature of the working environment and the flexible family support that the University provides. The Institute holds a silver Athena SWAN award in recognition of on-going commitment to ensuring that the Athena SWAN principles are embedded in its activities and strategic initiatives.
Research project related enquiries should be made in the first instance to Dr Sunil Jit Logantha ([Email Address Removed]). All general enquiries should be directed to Mrs Eleanor Toole ([Email Address Removed]).
To apply please send your CV and a covering letter to Dr Sunil Jit Logantha ([Email Address Removed]).
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