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Time-resolved NMR of biomineralization by dissolution dynamic nuclear polarization

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  • Full or part time
    Prof Dennis Kurzbach
  • Application Deadline
    No more applications being accepted
  • Competition Funded PhD Project (Students Worldwide)
    Competition Funded PhD Project (Students Worldwide)

Project Description

The NMR / DNP group of the University Vienna (www.Vienna-DNP.at) is looking for a highly motivated student to carry out a PhD thesis project centered around novel (hyperpolarization) tools based on NMR spectroscopy for the characterization of biomineralization processes.

Our lab is working on combining dissolution dynamic nuclear polarization (DDNP) [1], a technique to improve signal intensities in NMR spectra, with time-resolved detection of biomolecular NMR spectra on milliseconds to minutes time-scales. Our lab is equipped with 7 state-of-the-art NMR devices and integrated in a fully equipped biochemistry facility.
The project is centered around the understanding of biomineralization processes, i.e. the ability of living organisms to produce solid tissue and aims at the development of time-resolved models that describe the mineralization events at an atomistic level of resolution to obtain a better understanding of the biological function of the underlying molecular interactions. In other words, an idea shell be developed of how biominerals form with time and of how individual atoms act at different points in time.
The interdisciplinary PhD project combines biochemical and biophysical research of medicinal and societal relevance with cutting-edge instrumentational and methodological developments of the NMR technology.

The successful candidate holds a relevant degree in physics, chemistry, biochemistry or a similar field. She/he will work on the development of NMR techniques such as ultrafast measurements in combination with signal-improved NMR to characterize the interaction of designer peptides with calcium phosphates and silicates. These experiments allow determining the state of a protein in less than 1 s, which will eventually allow one to develop a model of the mineral formation to guide future developments in materials design and fundamental biophysics.

The University of Vienna aims at increasing the employment of women in both managing and academic positions and therefore invites applications from qualified female candidates.

The University of Vienna offers
• a dynamic research location with well-established research funding provisions
• attractive working conditions in a city with a high quality of life
• comprehensive advice and support in relation to finding an accommodation, change of schools and dual career
• a wide range of support services offered by central service institutions

Funding Notes

A four-year PhD thesis is available at the biological chemistry department of the University Vienna.

Applications including a letter of motivation (German or English) should be submitted directly to [Email Address Removed] no later than 07.05.2019.

References

[1] Dennis Kurzbach, Sami Jannin: Dissolution Dynamic Nuclear Polarization Methodology and Instrumentation, eMagRes, 2018, 7, DOI: 10.1002/9780470034590.emrstm1563.

[2] Giuseppe Sicoli, Hervé Vezin, Karin Ledolter, Thomas Kress, Dennis Kurzbach: Conformational tuning of a DNA-bound transcription factor. Nucl. Acids. Res. 2019, DOI: 10.1093/nar/gkz291.



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