There is huge scope to replicate the complex nature of tissue, through the design and additive manufacturing (3D printing, 3DP) of biomaterials. Extrusion-based bioprinting of hydrogels, has been shown to create orthotropic, viscoelastic and hyperelastic material properties. This is of interest to the replication of many types of tissue, and in this project will be investigated with relation to arteries. Arterial tissue has a distinct 3 layered structure, of which the mechanical properties vary greatly depending on location in the cardiovascular tree and disease pathology. Replicating the mechanical properties of such tissue is of great interest, either as a base for a tissue scaffold or graft, or vessel mimicking materials used for the development of diagnostic tools and interventions.
To date, extrusion-based bioprinting of hydrogels, has been shown to create orthotropic properties relative to the toolpath [1]. Furthermore, combining the mechanical properties of hydrogels, within an upscaled in-silico model, has shown that design of interfaces, relative to a multi-layered graft influences the intramural stress distribution [2]. This research project will utilise a sub-zero bioprinter to explore the topological parameters within the toolpath design of 3DP hydrogels, and the effect on the mechanical properties of the specimen. The characterised mechanical properties will be implemented into an in-silico model, to explore design parameters with respect to a multi-layered system. The project will require the applicant to be confident in laboratory skills and/or computational skills, ideally both. Experience of 3D printing is a desirable skill.
Applicants are expected to hold, or about to obtain, a first-class undergraduate Master’s degree (or equivalent) in engineering or a related subject (e.g. Chemistry, Physics, Maths, Materials Science). To apply please provide: (1) A curriculum vitae, (2) a cover letter summarising your research interests and experience relevant to the position, and (3) the contact details of two referees to Dr Lauren Thomas-Seale ([Email Address Removed])
All project-related enquiries should be sent to the project supervisor, Dr Lauren Thomas-Seale.