Total synthesis of marine polycyclic ether natural products to tackle Alzheimer’s disease
This project will develop an efficient asymmetric synthesis of marine polycyclic ether natural products. It has been established that marine polycyclic ether natural products have immense medicinal potential as modulators of brain related disorders (such as Alzheimer’s disease) due to their neurotoxicity, which results from their ability to interact with Na+ and K+-gated ion channels. In this project the candidate will develop an asymmetric synthesis of marine polycyclic ethers (such as gymnocin A and B) using an innovative desymmetrisation approach.
Our approach will significantly increase the synthetic efficiency compared to current strategies, therefore facilitating the neurotoxicity of the natural products (and precursors) to be established using existing assays. This will conceivably lead to an improved understanding of their mode-of-action, unlocking their medicinal potential as modulators of brain related disorders such as Alzheimer’s disease. The prospective PhD candidate will receive an excellent training platform in synthetic organic chemistry in our new state-of-the-art laboratories here at Loughborough.
Entry requirements Applicants should have, or expect to achieve, at least a 2:1 Honours degree (or equivalent) in Chemistry.
A relevant Master's degree and / or experience in one or more of the following will be an advantage: Chemistry.
All students must also meet the minimum English Language requirements: https://www.lboro.ac.uk/international/apply/english-language-requirements/
How to apply
All applications are made online, please select the school/department name under the programme name section and include the quote reference number: CM/MK-Un2/2019
This is an open call for candidates who are sponsored or who have their own funding. If you do not have funding, you may still apply, however Institutional funding is not guaranteed. Outstanding candidates (UK/EU/International) without funding will be considered for funding opportunities which may become available in the School.