About the Project
The majority of our existing antibacterial armamentarium are microbial products; despite this, most antibacterial drug discovery programmes have abandoned the search for novel natural product antibiotics, favoring instead rational synthetic chemistry approaches which have yet to bear fruit.
The proposed studentship intends to utilize several innovative approaches to find and characterize novel antibiotic classes produced by micro-organisms, with a view to ultimately developing drugs active against multi-drug resistant bacterial pathogens such as Staphylococcus aureus and Pseudomonas aeruginosa.
Talbot, G. H., Bradley, J., Edwards Jr., J. E., Gilbert, D., Scheld, M., Bartlett, J. G., et al. (2006). Bad bugs need drugs: an update on the development pipeline from the Antimicrobial Availability Task Force of the Infectious Diseases Society of America. Clin Infect Dis., 42 (5), 657-68.
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