Toxicological Assessment of Nanomaterials towards the development of a Nanotoxocicology Framework

The use of sophisticated delivery systems that allow the delivery and targeting of anti-cancer drugs into tumour tissue is an ever expanding area of research. In particular, the use of drug delivery systems (DDS) to deliver anticancer therapeutics has recently attracted a lot of interest. Although the mechanisms of action of the anti-cancer drugs that are usually attached to these delivery systems are well understood; the effect of the nano-based delivery systems on cells is not systematically understood.

Hence, in this project we aim to explore the effects of a range of pristine and functionalised nanomaterials (such as carbon nanotubes, graphene oxide, silver, gold , silica nanoparticles) on different types of healthy and cancer cells such A549 (lung), MCF7 (breast), DU145 (prostate) and HCT116 (colorectal), SHY5Y (neuronal) and normal HEK293 (kidney embryonic) cells. To achieve this, a series of molecular biology techniques, cell culture and toxicity experiments will be used as well as preparation and characterisation of nanoparticles will be employed.

Informal enquiries should be directed to Dr Hanene Ali-Boucetta, email: [Email Address Removed]

https://www.birmingham.ac.uk/staff/profiles/clinical-sciences/Ali-Boucetta-Hanene.aspx

To be considered for this studentship, please send the following documents to Dr Hanene Ali-Boucetta [Email Address Removed]:

• A detailed CV, including your nationality and country of birth;

• Names and addresses of two referees;

• A covering letter highlighting your research experience/capabilities;

• Copies of your degree certificates with transcripts;

• Evidence of your proficiency in the English language, if applicable.