Tracking and Modelling of Cell Dynamics with Application to Swarm Robots at University of Sheffield on FindAPhD.com

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Prof Visakan Kadirkamananthan Applications accepted all year round Self-Funded PhD Students Only

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Sheffield United Kingdom Electrical Engineering Electronic Engineering Software Engineering

Department of Automatic Control and Systems Engineering, University of Sheffield

About the Project

Understanding the dynamics of cell behaviour has the potential to lead to identifying the mechanisms of diseases such as cancer and of immune function. The increasingly sophisticated measurement techniques in life science has given rise to high resolution high throughput screening and in-vivo time lapse image sequences. Such image sequences contain single cell and population level information. Changes in patterns of cell behaviour can be associated with potential effectiveness of a therapeutic drug.

The aim of this project is to analyse such image sequences and extract cell motion / shape characteristics and their change over time for individual cells and across the cell population. It will require tracking the cell motion and characterising their behaviour patterns. Additionally, the cell shape features will be identified and associated with cell motion. Correlations between motion patterns and cell shapes will be analysed and quantified. An important aspect will be to quantitatively assess changes in cell behaviour under different drug environments. This understanding will then be incorporated into swarm robots for suitable applications.

Funding Notes

This is a self-funded research project.
We require applicants to have either an undergraduate honours degree (1st) or MSc (Merit or Distinction) in a relevant science or engineering subject from a reputable institution.
Prospective candidates for this project should have excellent mathematical and computational skills. Knowledge of signal processing methods such as target tracking, signal interpolation, model-based methods is desirable.
Full details of how to apply can be found at the following link:
https://www.sheffield.ac.uk/acse/research-degrees/applyphd
Applicants can apply for a Scholarship from the University of Sheffield but should note that competition for these Scholarships is highly competitive: https://www.sheffield.ac.uk/postgraduate/phd/scholarships

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