References
Relevant lab publications:
1. Budzak, J., Kerry, L.E., Aristodemou, A., Hall, B.S., Witmer, K., Kushwaha, M., Davies, C., Povelones, M.L., McDonald, J.R., Sur, A., Myler, P.J. and Rudenko G. (2019) Dynamic colocalization of 2 simultaneously active VSG expression sites within a single expression-site body in Trypanosoma brucei. Proceedings National Academy of Sciences 116(33), 16561-16570.
2. Ooi, C.P., Smith, T.K., Gluenz, E., Wand, N.V., Vaughan, S. and Rudenko G. (2018) Blocking Variant Surface Glycoprotein synthesis alters endoplasmic reticulum exit sites/ Golgi homeostasis in Trypanosoma brucei. Traffic 19: 391-405.
3. Ridewood, S., Ooi, C.P., Hall, B., Trenaman, A., Wand, N.V., Scherwitzl, I., Narayanan, M.S. and Rudenko G. (2017) The role of genomic location and flanking 3’UTR in the generation of functional levels of Variant Surface Glycoprotein in Trypanosoma brucei. Molecular Microbiology 106(4), 614-634.
4. Maree, J.P., Povelones, M.L., Clark, D.J., Rudenko, G., Patterton, H.G. (2017) Well positioned nucleosomes punctuate polycistronic Pol II transcription units and flank silent VSG gene arrays in Trypanosoma brucei. Epigenetics & Chromatin 10:14.
5. Kerry, L.E., Pegg, E.E., Cameron, D.P., Budzak, J., Poortinga, G., Hannan, K., Hannan, R.D. and Rudenko G. (2017) Selective inhibition of RNA polymerase I transcription as a potential approach to treat African trypanosomiasis. PLoS Neglected Tropical Diseases 11(3): e0005432.
6. Cheung, J.L.Y., Wand, N.V., Ooi, C.P., Wheeler, R. and Rudenko G. (2016) Block in Variant Surface Glycoprotein synthesis increases Trypanosoma brucei susceptibility to phagocytosis by macrophages. PLoS Pathogens 12(11): e1006023.
7. Stanne, T., Narayanan, M.S., Ridewood, S., Ling, A., Witmer, K., Kushwaha, M., Wiesler, S., Wickstead, B., Wood, J. and Rudenko G. (2015) Identification of the ISWI chromatin remodeling complex of the early branching eukaryote Trypanosoma brucei. Journal of Biological Chemistry 290(45): 26954-26967.
8. Denninger V. and Rudenko G. (2014) FACT plays a major role in histone dynamics affecting VSG expression site control in Trypanosoma brucei. Molecular Microbiology 94(4) 945-962.
9. Narayanan M. and Rudenko G. (2013) TDP1 is an HMG chromatin protein facilitating RNA polymerase I transcription in African trypanosomes. Nucleic Acids Research 41(5): 2981-2992.