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Transcription factors mediating light input to the Arabidopsis circadian clock

  • Full or part time
  • Application Deadline
    Applications accepted all year round
  • Self-Funded PhD Students Only
    Self-Funded PhD Students Only

Project Description

The circadian clock is tightly tied to the light environment. Transcriptional feedback loops are able to generate a self-sustaining rhythm of approximately 24 hours which impinges on almost every aspect of physiology in higher organisms. However, light signals are essential to maintain an exact 24 hour rhythm.

In the model plant, Arabidopsis thaliana, an endogenous circadian rhythm is generated by a set of interlocked transcriptional feedback loops. Light directly affects the level of a number of the clock components in plants. The photoreceptors involved have been well characterised but the way in which they affect clock components is only beginning to be understood.

The transcription factors, FHY3 and FAR1, play a key role in light input to the clock positively regulating transcription of key clock components. As a result, mutant seedlings specifically display aberrant circadian rhythmicity in the light. This project will analyse the mechanism by which FHY3 and FAR1 can fine-tune the clock throughout the cycle of day and night.

Further details:


Siddiqui H, Khan S, Rhodes BM, Devlin PF (2016) Frontiers in Plant Science In press
Edwards KD, Guerineau F, Devlin PF and Millar AJ (2015) bioRxiv DOI: 10.1101/030577
Smieszek SP, Yang H, Paccanaro A, Devlin PF (2014) J. Roy Soc Interface 11, pii: 20140535.
Li G, Siddiqui H, Teng Y, Lin R, Wan X, Li J, Lau O, Ouyang X, Dai M, Wan J, Devlin PF, Deng XW and Wang H (2011) Nature Cell Biology 13, 616-22
Wang X, Roig-Villanova I, Khan S, Shanahan H, Quail PH, Martinez-Garcia J and Devlin PF (2011) Journal of Experimental Botany 62, 2973-87

How good is research at Royal Holloway, University of London in Biological Sciences?

FTE Category A staff submitted: 24.00

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