About the Project
Using a combination of molecular biology, biochemistry, functional genomics and bioinformatics, the student will assess how these two processes can co-exist in the genome and how exactly in disease-related contexts transcription can become an impairment for DNA replication, inducing DNA damage and genome instability.
RECQL5 controls transcript elongation and suppresses genome instability associated with transcription stress. M Saponaro et al., Cell 157 (5), 1037-1049, 2014
UV irradiation induces a non-coding RNA that functionally opposes the protein encoded by the same gene L Williamson, M Saponaro, et al., Cell 168 (5), 843-855. e13, 2017
Mutation of cancer driver MLL2 results in transcription stress and genome instability. T Kantidakis, M Saponaro et al., Genes & development 30 (4), 408-420, 2016
Why not add a message here
Based on your current searches we recommend the following search filters.
Based on your current search criteria we thought you might be interested in these.