About the Project
This PhD project will investigate how ISC maintenance and differentiation change during aging, focusing on some of the key transcription factors important for ISC maintenance and differentiation. This project will allow you to build skills working with different types of whole genome datasets (RNA-Seq, DamID) as well as building skills in genetics, molecular biology and image analysis. We will e.g. perform crosses with inducible expression of RNAi’s, lifespan assays, microdissection and staining of gut tissue and FACS-isolation of midgut cell populations for whole genome RNA-sequencing.
You will work in the dynamic environment of the School of Biosciences at the University of Kent. The School of Biosciences has a rich expertise on Cancer and Ageing research, and we will have close connections to the ageing-related research in the labs of Dr. Jennifer Tullet and Dr. Marina Ezcurra. You will also be able to work with our collaborators in Germany at renowned institutes such as the Max Planck Institute for Biology of Ageing in Cologne and the FLI-Leibniz Institute on Aging in Jena as well as Genentech Inc. in San Francisco, U.S.A.
We are looking for a curiosity-driving student that works both independently and as part of a team and is interested in a multi-disciplinary research project. The ideal candidate should have knowledge of molecular biology techniques such as DNA/RNA-isolation, PCR and cloning as well as genetics. Additional experience in either Drosophila husbandry and genetics, bio-informatics or immunohistochemistry and confocal microscopy would be an advantage. Excellent writing and communication skills in English are necessary.
The Graduate Teaching Assistantship (GTA) provides a postgraduate research student with financial support in return for 96 hours per year of teaching. The stipend paid equals the full UK Research Council rate plus tuition fees at the home/EU rate. International applicants should make provision to meet the difference between Home /EU and International fees.
Stipend equals UK Research Council rate of £15,285 (rate for 2020/21), plus tuition fees covered at the rate for UK/EU students.
UK, EU and overseas fee paying students are invited to apply. International applicants should make provision to meet the difference between Home /EU and International fees. Please note that overseas students must have the appropriate documentation to evidence eligibility to work in the UK
Enquire with a CV and cover letter directly to: [Email Address Removed]
Applications can be made using the online University application page where the project title should be entered as the proposed area of research and Dr Jerome Korzelius as supervisor. Please include a CV and a cover letter Further scholarship details can be found at:
Escargot maintains stemness and suppresses differentiation in Drosophila intestinal stem cells. Korzelius J, Naumann SK, Loza-Coll MA, Chan JS, Dutta D, Oberheim J, Gläßer C, Southall TD, Brand AH, Jones DL, Edgar BA. EMBO J. 2014 Dec 17;33(24):2967-82. doi: 10.15252/embj.201489072.
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