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Transient nuclear protein-protein interaction networks

Project Description

Many processes implicated in the regulation of DNA transcription are driven by highly modular protein-protein interaction networks that are not exclusively maintained by the well structured protein domains but also by highly dynamic regions of interacting proteins. The aim of the doctoral project will be an identification as well as investigation of the physiological and pathological roles of these transient interactions using highly interdisciplinary approach, including protein biochemistry, biophysics, cell and structural biology.

How to apply

To apply for a PhD study at IOCB Prague, you must hold a Master’s degree (MSc) or the equivalent of the MSc in similar field (four or five year undergraduate degree). The application can be submitted before obtaining the Master’s degree, however, the applicant should obtain the degree within five months after the application deadline.

For more information visit our website “Call for PhD applications 2019”:

You can apply online via our application form


All general enquiries should be directed to Katerina Solcova (). Scientific enquiries can be addressed to the supervisor ().

Funding Notes

Regular monthly income of students at IOCB Prague varies depending on the faculty scholarship and supervisor's financial options.


1. Sharma, S., et al., Affinity switching of the LEDGF/p75 IBD interactome is governed by kinase-dependent phosphorylation. Proc Natl Acad Sci U S A, 2014. 115 (30): E7053
2. Těšina, P., et al., Multiple cellular proteins interact with LEDGF/p75 through a conserved unstructured consensus motif. Nature Communications, 2015. 6: 7968

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