Many processes implicated in the regulation of DNA transcription are driven by highly modular protein-protein interaction networks that are not exclusively maintained by the well-structured protein domains but also by highly dynamic regions of interacting proteins. The aim of the doctoral project will be an identification as well as investigation of the physiological and pathological roles of these transient interactions in chromatin remodeling and transcription regulation using a highly interdisciplinary approach, including protein biochemistry, biophysics, cell, and structural biology.
How to apply
To apply for a PhD study at IOCB Prague, you must hold a Master’s degree (MSc) or the equivalent of the MSc in similar field (four or five year undergraduate degree). The application can be submitted before obtaining the Master’s degree, however, the applicant should obtain the degree within five months after the application deadline.
For more information visit our website “Call for PhD applications 2020”: https://www.uochb.cz/en/phd-program
If you decided to apply, please do so online via our application form: https://www.uochb.cz/en/call-for-phd-applications
Sharma, S., et al., Affinity switching of the LEDGF/p75 IBD interactome is governed by kinase-dependent phosphorylation. Proc Natl Acad Sci U S A, 2014. 115 (30): E7053
Těšina, P., et al., Multiple cellular proteins interact with LEDGF/p75 through a conserved unstructured consensus motif. Nature Communications, 2015. 6: 7968