About the Project
Our group has shown that appending an anaplastic lymphoma kinase (ALK) inhibitor such as Crizotinib to heptamethine cyanine dyes dramatically improves the antiproliferative activity of Crizotinib in patient-derived GBM cell lines. Similar drug dye conjugates are being explored to see their effect on Temolozomide resistant patient-derived GBM cell lines.
We are currently looking for enthusiastic PhD students to join this exciting project. The prospective student will be able to hone their synthetic medicinal chemistry skills in a modern drug discovery laboratory which has so far brought 12 drug candidates to clinical trial. The student is expected to have courses in synthetic organic chemistry during their undergraduate/ honours/master’s programme. Laboratory experience in synthetic/medicinal chemistry is desirable.
Eligibility: Applicants must have completed a postgraduate bachelors (honours) degree with first class or second class (division 1) honours, or a masters degree with first class or second class (division 1) honours in Chemistry. In addition you completed a significant research project, dissertation or thesis, at university level.
Grades or marks achieved at other institutions are given a Grade Point Equivalent (GPE) on the University’s 0-9 grading scale. If you have overseas qualifications you will typically need a GPE of 5.5 or over 8.0 to be eligible for a University of Auckland Doctoral Scholarship. We highly recommend that you calculate your GPE before applying. To view an indication of your GPE use our GPE calculator: https://www.gpecalculator.auckland.ac.nz
Additional information about the University of Auckland Doctoral Entry requirements can be found here:
Fees: If you are a new international PhD student, you will pay the same annual tuition fee as New Zealand PhD students. The 2019 PhD tuition fee is NZ$7,108.80 per annum. In additional to the tuition fee, there is a Student Services Fee estimated at $847.20 for full-time study.
2. Usama, S. M.; Zhao, B.; Burgess, K., A Near-IR Fluorescent Dasatinib Derivative That Localizes in Cancer Cells. Bioconjug Chem 2019, 30, 1175-1181.
3. Choi, P.; Noguchi, K.; Ishiyama, M.; Denny, W. A.; Jose, J., A mitochondria-selective near-infrared-emitting fluorescent dye for cellular imaging studies. Bioorg Med Chem Lett 2018, 28, 2013-2017.
4. Usama, S. M.; Jiang, Z.; Pflug, K.; Sitcheran, R.; Burgess, K., Conjugation of Dasatinib with MHI-148 Has a Significant Advantageous Effect in Viability Assays for Glioblastoma Cells. ChemMedChem 2019.
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