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Ubiquitin and ubiquitin-like proteins in the DNA damage response and cancer


   Faculty of Biology, Medicine and Health


About the Project

A self-funded PhD studentship is available in the laboratories of Christine Schmidt, Stefan Meyer and Anthony Whetton. The project aims to study how posttranslational modifications with ubiquitin and ubiquitin-like proteins regulate the DNA damage response, and how dysregulation of these pathways in cancer cells could be exploited towards the development of novel anti-cancer drug targets.

Websites:

https://www.research.manchester.ac.uk/portal/christine.schmidt.html

http://www.mcrc.manchester.ac.uk/

http://www.cruk.manchester.ac.uk/

http://www.christie.nhs.uk/

Entry Requirements

Candidates are expected to hold (or be about to obtain) a minimum upper second class honours degree (or equivalent) in a related area/subject. Candidates with previous laboratory experience, particularly in cell culture and molecular biology, are particularly encouraged to apply.

How To Apply

For information on how to apply for this project, please visit the Faculty of Biology, Medicine and Health Doctoral Academy website (https://www.bmh.manchester.ac.uk/study/research/apply/). Informal enquiries may be made directly to the primary supervisor. On the online application form select PhD Genetics

For international students, we also offer a unique 4 year PhD programme that gives you the opportunity to undertake an accredited Teaching Certificate whilst carrying out an independent research project across a range of biological, medical and health sciences.

Equality, Diversity and Inclusion

Equality, diversity and inclusion is fundamental to the success of The University of Manchester, and is at the heart of all of our activities. The full Equality, diversity and inclusion statement can be found on the website https://www.bmh.manchester.ac.uk/study/research/apply/equality-diversity-inclusion/”

For international students we also offer a unique 4 year PhD programme that gives you the opportunity to undertake an accredited Teaching Certificate whilst carrying out an independent research project across a range of biological, medical and health sciences. For more information please visit http://www.internationalphd.manchester.ac.uk


Funding Notes

Applications are invited from self-funded students. This project has a Band 3 tuition fees. Details of our different fee bands can be found on our website (View Website).
Equality, diversity and inclusion is fundamental to the success of The University of Manchester, and is at the heart of all of our activities. The full Equality, diversity and inclusion statement can be found on the website View Website

References

• Cabello-Lobato MJ, Jenner M, Loch CM, Jackson SP, Wu Q, Cliff MJ, Schmidt CK. Microarray screening reveals a non-conventional SUMO-binding mode linked to DNA repair by non-homologous end-joining. bioRxiv (2021). DOI: 10.1101/2021.01.20.427433.
• Osborne HC, Irving E, Schmidt CK. The ubiquitin/UBL drug target repertoire. Trends in Molecular Medicine (2020). DOI: 10.1016/j.molmed.2020.08.009.
• Schmidt CK, Galanty Y, Sczaniecka-Clift M, Coates J, Jhujh S, Demir M, Cornwell M, Beli P, Jackson SP. Systematic E2 screening reveals a UBE2D–RNF138–CtIP axis promoting DNA repair. Nat. Cell Biol (2015). 17, 1458–1470.
• Paredes R, Schneider M, Stevens A, Pierce A; White D, Williamson A, Muter J, Pearson S, Kelly J, Connors K, Wiseman D, Chadwick J Loeffler H, Teng HY, Lovell S, Unwin R, van de Vrugt H, Smith H, Kustikova O, Schambach A, Somervaille T, Whetton AD, Meyer S. EVI1 carboxy-terminal phosphorylation is ATM-mediated and sustains transcriptional modulation and self-renewal via enhanced CtBP1 association. Nucleic Acids Res. (2018). 15, 7662-7674. doi: 10.1093/nar/gky536.
• Taylor AMR, Rothblum-Oviatt C, Ellis NA, Hickson ID, Meyer S, Crawford TO, Smogorzewska A, Pietrucha B, Weemaes C, Stewart GS. Chromosome instability syndromes. Nat Rev Dis Primers (2019). 1, 64. doi: 10.1038/s41572-019-0113-0

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