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Ubiquitin binding and the assembly of ubiquitin chains

  • Full or part time
  • Application Deadline
    Applications accepted all year round
  • Funded PhD Project (Students Worldwide)
    Funded PhD Project (Students Worldwide)

Project Description

A talented PhD candidate interested in studying the biochemical properties of ubiquitin E3-ligases is being recruited to join Catherine Day’s laboratory in the Biochemistry Department, University of Otago, Dunedin, New Zealand.

In this project you will investigate how ubiquitin binding sites on a RING E3 ligase influences the assembly of ubiquitin chains. The broad aim of this project is to elucidate the molecular details that regulate ubiquitin attachment, with a focus on revealing features that promote assembly of ubiquitin chains. This builds on research in my laboratory as well as others, which have shown that ubiquitin binding domains can enhance chain assembly. Assay systems and many reagents that underpin this project are available. More details about research in the Day laboratory are available at https://www.otago.ac.nz/biochemistry/people/profile/index.html?id=254.

Highly motivated individuals with a BSc(Hons) or MSc in Molecular Biology, Biochemistry, or related discipline are encouraged to apply. The ideal candidates will have practical knowledge in expression construct design and optimization, as well as protein purification. Experience in analysis of ubiquitin, structure determination methods and other biophysical methods is an advantage. Excellent communication skills, willingness to work in a team, and the ability to plan and interpret experiments in an independent manner are important attributes. The ability to communicate proficiently in English is essential. Formal english language requirements can be found at http://www.otago.ac.nz/study/entrance/otago001300.html#minp

Funding Notes

A fully funded project that includes an annual stipend, registration fees and consumable costs is available.

Include in your application:
(i) a copy of your CV,
(ii) a copy of your academic transcript,
(iii) a short motivation statement (~500 words), and
(iv) a pdf copy of your research thesis.

The ability to communicate proficiently in english is essential.

Applicants must be eligible for admission to the PhD programme at the University of Otago and be eligible for a scholarship (View Website). A GPA of equivalent to an Otago GPA of 8.0 or greater is essential.

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