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Ubiquitylation pathways in the DNA damage response


Faculty of Biology, Medicine and Health

About the Project

A self-funded PhD studentship is available in Dr Christine Schmidt’s laboratory at the newly built Manchester Cancer Research Centre. The project aims to study how ubiquitylation pathways regulate the DNA damage response (DDR) and genome stability, and to identify novel anti-cancer drug targets.

To achieve the goal of this project the appointee will apply a range of techniques, for which training will be provided: cell biology, biochemistry, biophysics and quantitative high-throughput/high-content imaging methods, as well as mass spectrometry proteomics and CRISPR/Cas9 gene-editing technology.

Website:
https://www.research.manchester.ac.uk/portal/christine.schmidt.html


Funding Notes

The successful candidate will be highly motivated and hold a first-class degree in a relevant biological science.

This project has a Standard fee. Details of our different fee bands can be found on our website (View Website). For information on how to apply for this project, please visit the Faculty of Biology, Medicine and Health Doctoral Academy website (View Website).

Informal enquiries may be made directly to the primary supervisor.

References

Schmidt, C.K., Galanty, Y., Sczaniecka-Clift, M., Coates, J., Jhujh, S., Demir, M., Cornwell, M., Beli, P., and Jackson, S.P. (2015). Systematic E2 screening reveals a UBE2D–RNF138–CtIP axis promoting DNA repair. Nat. Cell Biol. 17, 1458–1470.

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