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Ultrafast Imaging of Cell-Nanobubble Interactions for Bone Repair

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  • Full or part time
    Dr N Evans
    Dr D Carugo
  • Application Deadline
    No more applications being accepted
  • Funded PhD Project (UK Students Only)
    Funded PhD Project (UK Students Only)

Project Description

Acoustic bubbles can be loaded with drugs and resonate when excited by ultrasound. This property allows us to research their use in medicine – for example, we think that ultrasound from outside the body can be used to stimulate bubbles to release drugs to the right cells at the right time. However, to fully take advantage of this technology, we need a better understanding of the interactions between bubbles and cells. Ultrafast imaging offers us this opportunity.

During this PhD you will develop microscopy techniques to image ultrafast oscillations of bubbles. You will image bubbles under ultrasound stimulation at a frame rate of up to 10 million frames per second. You will track the interactions of bubbles with bone cells using this technique, and determine how drugs are released in proximity to cells.

You will work in a vibrant, multidisciplinary team between the Faculties of Medicine and Engineering at the University. You need to have at least a 2:1 or equivalent and ideally you will have a background in physics or engineering, but we encourage applications from talented individuals with backgrounds in the natural sciences.

If you wish to discuss any details of the project informally, please contact Nicholas Evans or Dario Carugo, Bioengineering research group, Email: [Email Address Removed] or [Email Address Removed]

Funding Notes

This 3 year studentship covers UK tuition fees and provides an annual tax-free stipend at the standard EPSRC rate, which is £14,777 for 2018/19. As part of the selection process, the strength of the whole application is taken into account, including academic qualifications, personal statement, CV, references.

Applicants must be UK residents with no restrictions on how long they can stay in the UK and have lived here for at least 3 years prior to the start of the studentship. This residence cannot be mainly for the purpose of receiving full-time education. For further guidance on funding, please contact [Email Address Removed]

How good is research at University of Southampton in General Engineering?

FTE Category A staff submitted: 192.23

Research output data provided by the Research Excellence Framework (REF)

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