About the Project
The project will involve scanning, transmission and 3D electron microscopy together with immunoelectron microscopy, light microscopy and gene analysis. In addition, skills in parasitology will be gained including maintenance of parasite life cycles and experimental animal work.
Candidates are expected to hold (or be about to obtain) a minimum upper second class honours degree (or equivalent) in a biologically related area. Candidates with experience in parasitology , imaging and/ or with an interest in electron microscopy are encouraged to apply.
For international students we also offer a unique 4 year PhD programme that gives you the opportunity to undertake an accredited Teaching Certificate whilst carrying out an independent research project across a range of biological, medical and health sciences. For more information please visit http://www.internationalphd.manchester.ac.uk
As an equal opportunities institution we welcome applicants from all sections of the community regardless of gender, ethnicity, disability, sexual orientation and transgender status. All appointments are made on merit.
White EC, Houlden A, Bancroft AJ, Hayes KS, Goldrick M, Grencis RK, Roberts IS (2018) Manipulation of host and parasite microbiotas: Survival strategies during chronic nematode infection. Science Advances. 2018 Mar 14;4(3):eaap7399. doi: 10.1126/sciadv.aap7399.
Houlden A, Hayes KS, Bancroft AJ, Worthington JJ, Wang P, Grencis RK, Roberts IS. (2015) Chronic Trichuris muris Infection in C57BL/6 Mice Causes Significant Changes in Host Microbiota and Metabolome: Effects Reversed by Pathogen Clearance. PLoS One.10(5):e0125945. PMID: 25938477.
Foth BJ, Tsai IJ, Reid AJ, Bancroft AJ, Nichol S, Tracey A, Holroyd N, Cotton JA, Stanley EJ, Zarowiecki M, Liu JZ, Huckvale T, Cooper PJ, Grencis RK, Berriman M (2014) Whipworm genome and dual-species transcriptome analyses provide molecular insights into an intimate host-parasite interaction. Nature Genetics. 46, 693-700. PMID: 24929830. Hayes, K.S., Bancroft, A.J., Goldrick, M., Portsmouth, C., Roberts I.S.& Grencis, R.K. (2010) Exploitation of the intestinal microflora by the parasitic nematode Trichuris muris: microflora regulates macrofauna. Science. 328, 1391-4. PMID: 20538949.
Cliffe LJ, Humphreys NE, Lane TE, Potten CS, Booth C and Grencis RK (2005) Accelerated intestinal epithelial cell turnover: a new mechanism of parasite expulsion. Science. 308, 1463-1465. PMID: 15933199.
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