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About the Project
PHD POSITION IN CRANIO- AND OROFACIAL DEVELOPMENT
The research group “Cranio- and orofacial development” at the University Hospital Leipzig (UKL) offers a fully funded PhD position. The candidate should have a strong interest in craniofacial development and profound knowledge of molecular biology.
Our interests: This research project will focus on uncovering the molecular mechanisms that drive orthodontic tooth movement. By utilizing cutting-edge spatial transcriptomics, we aim to create a detailed molecular atlas of gene expression within the periodontium. For this a set of cutting-edge methods such as spatial transcriptomics sequencing, advanced bioinformatics analyses, novel in situ hybridization methods, transgenic mouse models, computed tomography and 3D imaging are employed throughout the investigation. The experimental procedures further comprise standard molecular methods such as immunohistochemistry, histology, in vitro cell and tissue cultivation. This research will reveal key biological processes during orthodontic tooth movement within the hard and soft tissue, with the goal of developing novel therapeutic strategies to improve orthodontic treatment outcomes.
Requirements: MSc degree or Diploma in Biology, Molecular Biology, Biochemistry, Biotechnology, Bioinformatics or Chemistry; profound knowledge of craniofacial development and molecular biology; previous experience working with animal models is a benefit, but not requirement; knowledge and experience with bioinformatic analysis (coding in R/Python) is an advantage.
The Research Group: Our international team possesses expertise in molecular, developmental biology and genetics and closely collaborates with the clinical section of UKL and other international partners (Max Planck Institute in Ploen, Masaryk University in Czech Republic, Karolinska Institute in Sweden, and others). We offer access to state-of-the-art equipment, a supportive, motivating and inspiring work environment, as well as personal and professional development by attending conferences and courses.
Applicants with a strong motivation for a career in science, excellent laboratory, and organizational skills are welcome to apply.
Where to apply: Please send a cover letter with the description of your previous research experience and motivation to join our lab; curriculum vitae; a certified copy of your qualifications (degree, diploma or animal course certificates) and the contact details of two referees to: julian.petersen@medizin.uni-leipzig.de
References
Nottmeier, C., Lavicky, J., Gonzalez Lopez, M. et al. Mechanical-induced bone remodeling does not depend on Piezo1 in dentoalveolar hard tissue. Sci Rep 13, 9563 (2023). https://doi.org/10.1038/s41598-023-36699-9
Nottmeier C, Liao N, Simon A, Decker MG, Luther J, Schweizer M, Yorgan T, Kaucka M, Bockamp E, Kahl-Nieke B, Amling M, Schinke T, Petersen J, Koehne T. Wnt1 Promotes Cementum and Alveolar Bone Growth in a Time-Dependent Manner. J Dent Res. 2021 Dec;100(13):1501-1509. doi:10.1177/00220345211012386
Krivanek, J., Soldatov, R.A., Kastriti, M.E. et al. Dental cell type atlas reveals stem and differentiated cell types in mouse and human teeth. Nat Commun 11, 4816 (2020). https://doi.org/10.1038/s41467-020-18512-7
Nottmeier C, Liao N, Simon A, Decker MG, Luther J, Schweizer M, Yorgan T, Kaucka M, Bockamp E, Kahl-Nieke B, Amling M, Schinke T, Petersen J, Koehne T. Wnt1 Promotes Cementum and Alveolar Bone Growth in a Time-Dependent Manner. J Dent Res. 2021 Dec;100(13):1501-1509. doi:10.1177/00220345211012386
Krivanek, J., Soldatov, R.A., Kastriti, M.E. et al. Dental cell type atlas reveals stem and differentiated cell types in mouse and human teeth. Nat Commun 11, 4816 (2020). https://doi.org/10.1038/s41467-020-18512-7
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