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Understanding and controlling β-strand mediated PPIs using bespoke chemical modifications

   Faculty of Engineering and Physical Sciences

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  Prof A J Wilson, Dr Theodoros Karamanos  No more applications being accepted  Competition Funded PhD Project (Students Worldwide)

Leeds United Kingdom Biochemistry Biophysics Organic Chemistry Structural Biology

About the Project

Chemical probes are advantageous in studying the molecular mechanisms of health and disease; they uniquely allow temporary and titratable modulation of a target protein’s function, permitting evaluation of its functional role. Furthermore chemical probes represent starting points for drug-discovery.

This PhD studentship will exploit peptidomimetic design to develop chemical probes that can inhibit post-translation modification of proteins by small ubiquitin-related modifier (SUMO). SUMOylation regulates multiple cellular processes including transcription, replication, and DNA repair. SUMO interacting motifs (SIMs) play an important role in reading, writing and erasing SUMO. SIMs recognize SUMO through non-covalent interaction in a β-strand conformation and are typically found within intrinsically disordered regions of proteins. Here we will apply a state of the art combination of peptidomimetic design and advanced Nuclear Magnetic Resonance (NMR) experiments to identify and characterize chemical probes for a series of SIMS relevant to aggregation and DNA damage.

Funding Notes

A highly competitive BBSRC Doctoral Training Partnership Studentship consisting of the award of fees with a maintenance grant (currently £15,609 for session 2021/22) for 4 years. This opportunity is open to all applicants. Selection is based on academic merit.
The award also includes: Research Training and Support Grant (RTSG); Conference and Professional Internships for PhD Students (PIPS) allowances; and Centrally organised training and networking opportunities, including an annual student symposium.
Please refer to the UKCISA website for information regarding Fee Status for Non-UK Nationals starting from September/October 2021.
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