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  Understanding and separating biological and measurement variability in MRI: application to neuroimaging in children


   UCL Great Ormond Street Institute of Child Health

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  Prof Chris Clark  No more applications being accepted  Funded PhD Project (UK Students Only)

About the Project

A 4-year PhD Studentship funded by EPSRC is available within the Developmental Imaging and Biophysics Section in the Developmental Neuroscience Programme, Great Ormond Street UCL Institute of Child Health jointly with the National Physical Laboratory (NPL). The studentship will commence in October 2021 under the supervision of Professor Chris Clark (UCL) and Dr Matt Hall (NPL) and Dr Nadia Smith (NPL).

Our research group has a particular interest in using quantitative MRI methods to evaluate brain structure and function, these include diffusion MRI and arterial spin labelling, the latter for measuring cerebral blood flow. When these parameters are measured there is significant variability from one healthy subject to the next even when factors such as age, gender and IQ are corrected for. The key question which this PhD project addresses is how much is the variability due to genuine differences in biology and how much is due to the measurement process itself? The project builds on a longstanding collaboration with colleagues at the National Physical Laboratory that have expertise in measurement error. Improved understanding of the true measurement error will provide a clearer picture of the true biological variation and will allow the optimization of methods to improve the sensitivity of techniques used to diagnose and monitor diseases of the brain in children.

For further details, please see:

The student will receive a starting stipend of £17,609 per annum (including London weighting) as well as the cost of tuition fees based on UK fee status. 

Personal Specification

Applicants should have, or expect to receive an upper second-class Bachelor’s degree and a Master’s degree (or equivalent work experience) in a relevant discipline or an overseas qualification of an equivalent standard.

Eligibilty

This studentship covers the cost of tuition fees based on the UK (Home) rate. Non-UK students can apply but will have to personally fund the difference between the UK (Home) rate and the overseas rate where they are not eligible for UK fee status.

NB: You will be asked about your likely fee status at the interview so we would advise you to contact the UCL Graduate Admissions Office for advice should you be unsure whether or not you meet the eligibility criteria for Home fee status. Further information on Brexit and the definitions for fee status assessment can be found on the UCL website and also the UKCISA website (Higher Education: Definitions for fee status assessment).

Application

To apply, please send a current CV including the contact details of two professional referees as well as a cover letter to [Email Address Removed]. Enquiries regarding the post can be made to Prof Chris Clark ([Email Address Removed]).

Deadline for receipt of applications: 6th May 2021

Interview date: 13th May 2021


 About the Project