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Understanding asthma through population-scale long-read sequencing of diverse genomes

   Department of Genetics and Genome Biology

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  Dr E Hollox, Dr K Fawcett  No more applications being accepted  Competition Funded PhD Project (Students Worldwide)

About the Project

Understanding the diversity of human genomes is important for understanding the contribution of genetic variation to disease, including asthma. Despite much progress in understanding, we have very limited understanding in two areas – genomes from those of non-European ancestry, and complex genetic structural variation, such as variation in gene copy number variation. Using long read genome sequencing, two large projects (1000 Genomes Project and Genomics England) are beginning to address this. This project will use available long read sequences from under-represented individuals for genome structural variation. The project will focus on the role of these structural variants in respiratory disease, in particular asthma, but there will be opportunities to answer more fundamental biological questions on the population genetics of structural variants as well. 

Entry requirements

  • Entry requirements Candidates applying to the four-year PhD should hold or expect to hold an undergraduate degree or a Master's degree in a relevant subject or overseas equivalent
  • University of Leicester English language requirements apply


UK/ International* applicants may apply.

* International students please refer to the Funding section.

Enquiries to [Email Address Removed]

To apply please refer to the advice and application link at

Funding Notes

Studentships funding:
Four Years Fees at UK rates
Wellcome Trust stipend for the four years of the PhD*
*PhD Stipend
Year 1 £22,976
Year 2 £23,523
Year 3 £24,070
Year 4 £24,617
International students awarded the UK tuition fee waiver/stipend studentship will need to provide evidence that they can pay the difference between UK fees and international fees for the duration of their studies.
The difference between UK and International Fees to be paid by International students will be £17,138 per year (2023/4 entry)
(UK Fee for 2023/4 is £4,712 per year. International Fee for 2023/4 is £21,850 per year)
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