Understanding disease mechanisms of Alzheimer’s disease

Project reference number: SHLS19028

Alzheimer’s disease (AD) is the most common cause of dementia and is a growing global health concern in the world. AD is a complex diseases with involvement of genetic and environmental factors. Retina is part of central nervous system, sharing many functional pathways with brain. AD patients also present visual functional defects. Diagnosis of AD is usually carried out at late stage when dementia is already established, making difficult for effective treatment. In this project we plan to investigate visual function and physiology in AD animal model at different disease stages, which will help understand disease mechanisms, develop new drugs and set up useful measures for early diagnosis.

Aims
This PhD will focus on investigation of pathophysiological features in AD animal model. This student will examine visual function, retinal histology and inflammation, and evaluate therapeutic effects of some drug candidates.

Specifications
The successful applicant will be a qualified in Biomedical Science or related areas and hold the minimum of a first degree (2:1 or above). Previous experience in neurodegenerative diseases is desirable.
Candidates are requested to submit a more detailed research proposal (of a maximum of 2000 words) on the project area as part of their application.

Research Strategy and Research Profile
Glasgow Caledonian University’s research is framed around the United Nations Sustainable Development Goals, We address the Goals via three societal challenge areas of Inclusive Societies, Healthy Lives and Sustainable Environments. This project is part of the research activity of Research Group – Long Term Conditions.
https://www.gcu.ac.uk/hls/staff/drxinhuashu/


How to Apply
This project is available as a 3 year full-time PhD study programme with a start date of 1st October 2019
For information on how to apply and the online application form please go to
https://www.gcu.ac.uk/research/postgraduateresearchstudy/applicationprocess/
Applicants shortlisted for the PhD project will be contacted for an interview.