Understanding Fully Continuous Tablet Manufacturing Processes Using Experimental and Modelling Tools
A 4 year PhD studentship (co-funded by AstraZeneca) project to develop model predictive control of a fully continuous tablet manufacturing process.
The pharmaceutical industry is moving towards utilisation of continuous processing for manufacture of formulated medicinal products. This project aims to utilise the new Diamond Pilot Plant at Sheffield as a test bed to couple emerging mechanistic models with online sensors and process control as a basis for optimisation and control of tablet properties and performance, such as tensile strength and dissolution. Experimental methodologies will need to be developed to build and calibrate the models and full system runs will need to be performed to validate and demonstrate potential applications.
During the course of the project the student will be trained on the continuous powder to tablet line and product characterisation equipment available at Particle Product Group at the University of Sheffield and research facilities of AZ in Macclesfield, UK. This will give the student experience of performing research in an industrial environment and working with a well-established global group of experts in the granulation research area.
The candidate will be invited to attend the 9th international granulation conference in Switzerland as well as the 10th international granulation workshop and conference. Additionally, the candidate will be encouraged to attend other particle technology conferences locally and internationally.
Candidates should have a first class or upper second class degree in chemical engineering, control engineering, mathematics, material science, chemistry, or a related discipline.
This studentship is open to students from the UK and the European Union (EU) countries.