Understanding Hormone Regulation in Skin Cancer Development and Progression

Skin cancers, including melanoma and non-melanoma skin cancers, pose a significant global health burden. While the role of hormones in skin cancer development and progression remains an underexplored area, recent research has suggested potential links between hormonal regulation and skin cancer outcomes. This project aims to investigate the interplay between hormonal regulation, clinical trials, transdermal drug delivery, and therapeutic interventions in the context of skin cancer.

Objectives: Hormonal Regulation in Skin Cancers: The project will commence with a comprehensive study to elucidate the role of hormones, including sex hormones, thyroid hormones, and stress-related hormones, in the development and progression of skin cancers. Understanding these relationships will form the foundation of subsequent investigations.

Clinical Trials and Patient Outcomes: This research will involve the design and execution of clinical trials to assess the efficacy and safety of hormone-related therapeutic interventions in patients with skin cancer. The goal is to gather empirical evidence on how hormonal regulation can be leveraged to improve patient outcomes.

Transdermal Drug Delivery Systems: The project will also explore innovative transdermal drug delivery systems to administer hormone-based therapeutics. These systems will enhance patient comfort, adherence, and the localized delivery of therapeutic agents for effective skin cancer treatment.

Therapeutic Interventions: The project will investigate the development of hormone-based therapeutics as novel treatment modalities for skin cancers. This will include the design and testing of hormone-targeted drugs and their delivery via transdermal systems to evaluate their clinical efficacy.

Expected Outcomes:

• A deeper understanding of the role of hormonal regulation in skin cancer development.
• Empirical evidence from clinical trials on the effectiveness of hormone-based therapeutic interventions.
• Innovative transdermal drug delivery systems designed for skin cancer treatment.
• Novel hormone-based therapeutic agents developed to enhance patient care in skin cancer management.

This multifaceted project seeks to shed light on the complex relationship between hormonal regulation and skin cancers, ultimately aiming to improve treatment options and patient outcomes. The findings from this research have the potential to revolutionize the field of dermatological oncology and significantly impact the clinical management of skin cancers.

The York Biomedical Research Institute at the University of York is committed to recruiting extraordinary future scientists regardless of age, ethnicity, gender, gender identity, disability, sexual orientation, religion/belief, marital status, pregnancy and maternity, or career pathway to date. We understand that commitment and excellence can be shown in many ways and have built our recruitment process to reflect this. We welcome applicants from all backgrounds, particularly those underrepresented in science, who have curiosity, creativity and a drive to learn new skills.