About the Project
Applicants are encouraged to contact the Principal Supervisor directly to discuss the project. Candidates are expected to hold (or be about to obtain) a minimum upper second class honours degree (or equivalent) in a related area / subject. Candidates with experience in neuroscience or with an interest in immunology are encouraged to apply.
New boron based inhibitors of the NLRP3 inflammasome
Cell Chemical Biology, 2017, in press
Daniels MJD, Rivers-Auty J, Schilling T, Spencer NG, Watremez W, Fasolino V, Booth S, White CS, Baldwin AG, Freeman S, Wong R, Latta C, Yu S, Jackson J, Fischer N, Koziel V, Pillot T, Bagnall J, Allan SM, Paszek P, Galea J, Harte MK, Eder C, Lawrence CB, Brough D. Fenamate NSAIDs inhibit the NLRP3 inflammasome and protect against Alzheimer’s disease in rodent models. Nature Communications, 2016, 7:12504
Martín-Sánchez F, Diamond C, Zeitler M, Gomez-Sanchez A, Baroja-Mazo A, Bagnall J, Spiller D, White M, Mortellaro A, Peñalver M, Daniels MD, Paszek P, Steringer JP, Nickel W, Brough D*, Pelegrín P*. Inflammasome-dependent IL-1β release depends upon membrane permeabilisation. Cell Death and Differentiation, 2016, 23:1219-31
(*Joint senior and corresponding author)
Denes A, Coutts C, Lénárt N, Cruickshank SM, Pelegrin P, Skinner J, Rothwell N, Allan SM, Brough D. AIM2 and NLRC4 inflammasomes contribute with ASC to acute brain injury independently of NLRP3. Proc Natl Acad Sci, 2015, 112: 4050-4055
Baroja-Mazo A, Martín-Sánchez F, Compan V, Gomez AI, Barberà-Cremades M, Yagüe J, Ruiz-Ortiz E, Antón J, Buján S, Peñalver-Mellado M, Brough D, Aróstegui JI, Pelegrín P. The NLRP3 inflammasome is released as a particulate danger signal that amplifies the inflammatory response. Nature Immunology, 2014, 15:738-748
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