About the Project
In this project, you will use time-lapse microscopy and microfluidics to determine how cellular rhythms are generated. By studying metabolic cycling in single cells of baker’s yeast, you will discover insights into a fundamental cellular process. Combining single-cell fluorescence reporters with deletion mutants, you will work out which enzymes are crucial in generating the rhythms and, through analysing the single-cell time series, which properties of the rhythms they affect. Your results may substantially change how we understand cellular physiology.
The School of Biological Sciences is committed to Equality & Diversity: https://www.ed.ac.uk/biology/equality-and-diversity
Papagiannakis A, Niebel B, Wit EC, Heinemann M. Autonomous metabolic oscillations robustly gate the early and late cell cycle. Molecular Cell. 2017; 65:285-95.
Edgar RS, et al. Peroxiredoxins are conserved markers of circadian rhythms. Nature. 2012; 485:459-64.
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