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Understanding how multicellular bacteria divide (SCHLIMPERTJ20DTP)

  • Full or part time
  • Application Deadline
    Monday, November 25, 2019
  • Competition Funded PhD Project (European/UK Students Only)
    Competition Funded PhD Project (European/UK Students Only)

Project Description

Every cell must divide to grow and to propagate. While most bacteria simply split in half, the decision when and where to divide is more complex in multicellular bacteria like the antibiotic producing bacteria Streptomyces. In fact, Streptomyces have two functionally distinct modes of cell division that lead to the formation of multigenomic compartments and unigenomic spores.

The aim of this project is to better understand how multicellular bacteria divide and to characterise a recently identified novel cell division protein in Streptomyces. Components of the bacterial cell division machinery are also attractive targets for novel antimicrobials. Hence, new insights into the formation and function of the bacterial cell division machinery could help in the development of new strategies to inhibit cell division in disease-causing bacteria.

We are looking for an enthusiastic student interested in bacterial cell biology and who is keen to develop skills in molecular microbiology, biochemistry and fluorescence microscopy.
The successful candidate will be based in the laboratory of Dr Susan Schlimpert in the Department for Molecular Microbiology at the John Innes Centre, a world-leading institute for plant and Streptomyces research.

The student will have access to cutting-edge research facilities for bacterial genetics, live cell imaging and protein biochemistry, a vibrant graduate student community and a stimulating research environment. Through the project and the range of training opportunities available at the institute the student will obtain excellent technical and transferable skills that are highly relevant for working in academia or industry.

This project has been shortlisted for funding by the Norwich Biosciences Doctoral Training Partnership (NRPDTP). Shortlisted applicants will be interviewed as part of the studentship competition. Candidates will be interviewed on either the 7th, 8th or 9th January 2020.

The NRP DTP offers postgraduates the opportunity to undertake a 4-year research project whilst enhancing professional development and research skills through a comprehensive training programme. You will join a vibrant community of world-leading researchers. All NRPDTP students undertake a three-month professional internship (PIPS) during their study. The internship offers exciting and invaluable work experience designed to enhance professional development. Full support and advice will be provided by our Professional Internship team. Students with, or expecting to attain, at least an upper second-class honours degree, or equivalent, are invited to apply.

For further information and to apply, please visit our website: https://biodtp.norwichresearchpark.ac.uk/

Funding Notes

For funding eligibility guidance, please visit our website: View Website. Full Studentships cover a stipend (2019/0 rate: £15,009pa), research costs and tuition fees at UK/EU rate and are available to UK and EU students who meet the UK residency requirements.

Students from EU countries who do not meet the UK residency requirements may be eligible for a fees-only award. Students in receipt of a fees-only award will be eligible for a maintenance stipend awarded by the NRPDTP Bioscience Doctoral Scholarships. To be eligible students must meet the EU residency requirements.

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