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Understanding how systemic infection exacerbates Alzheimer’s disease

This project is no longer listed on FindAPhD.com and may not be available.

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  • Full or part time
    Dr MC Pardon
  • Application Deadline
    Applications accepted all year round
  • Self-Funded PhD Students Only
    Self-Funded PhD Students Only

Project Description

Systemic infection and inflammation are associated with the risk and progression of Alzheimer’s disease but the underlying mechanisms are unclear. Our research indicates that systemic infection can rapidly and directly modulate key brain hallmarks of Alzheimer’s disease: amyloid plaques deposition and neurofibrillary tangles. The project aims to understand the role played by peripheral pro-inflammatory cytokines induced in response to immune stimulation in this effect. The work will use in vivo and ex vivo approaches. (e.g. behavioural, pharmacological and molecular) in a preclinical model of Alzheimer’s disease.

The University of Nottingham is one of the world’s most respected research-intensive universities, ranked 8th in the UK for research power (REF 2014). Students studying in the School of Life Sciences will have the opportunity to thrive in a vibrant, multidisciplinary environment, with expert supervision from leaders in their field, state-of-the-art facilities and strong links with industry. Students are closely monitored in terms of their personal and professional progression throughout their study period and are assigned academic mentors in addition to their supervisory team. The School provides structured training as a fundamental part of postgraduate personal development and our training programme enables students to develop skills across the four domains of the Vitae Researcher Development Framework (RDF). During their studies, students will also have the opportunity to attend and present at conferences around the world. The School puts strong emphasis on the promotion of postgraduate research with a 2-day annual PhD research symposium attended by all students, plus academic staff and invited speakers.

Funding Notes

Home applicants should contact the supervisor to determine the current funding status for this project. EU applicants should visit the Graduate School webpages for information on specific EU scholarships http://www.nottingham.ac.uk/GraduateSchool/index.aspx. International applicants should visit our International Research Scholarships page for information regarding fees and funding at the University http://www.nottingham.ac.uk/studywithus/international-applicants/scholarships-fees-and-finance/index.aspx.

How good is research at University of Nottingham in Biological Sciences?

FTE Category A staff submitted: 90.86

Research output data provided by the Research Excellence Framework (REF)

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