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Understanding Multiple Antibiotic Resistance in Gram-negative Bacteria


School of Biosciences

, Dr J Blair Sunday, January 10, 2021 Competition Funded PhD Project (Students Worldwide)

About the Project

Antibiotics have transformed medical practice, increased life expectancy and, together with vaccination, led to the near eradication of many bacterial diseases. However, overuse, including in animals, has potentiated the emergence of resistant bacteria. Such bacteria now cause millions of infections annually, with thousands of lives lost at a societal cost of billions of dollars. Moreover, the occurrence of untreatable infections is increasingly common. This disturbing trend is an immediate threat to health in every region of the world; antibiotic-resistant bacteria have the potential to affect anyone, of any age, in any country. The multiple antibiotic resistance (mar) regulon, and homologous systems, are continually implicated. Briefly, the mar operon encodes a global gene regulatory system that controls expression of genetic determinants which confer antibiotic resistance. We hypothesise that the majority of targets for MarA, and the underlying molecular mechanisms of antibiotic resistance, are undefined. This project will combine genomic tools with focused molecular biology to identify new mechanisms of antibiotic resistance and new drug targets.

For more information about Professor Grainger’s lab and research please visit: http://graingerlab.com/

You are also advised to contact Professor Grainger directly to discuss your application prior to submission.

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To find out more about studying for a PhD at the University of Birmingham, including full details of the research undertaken in each school, the funding opportunities for each subject, and guidance on making your application, you can now order your copy of the new Doctoral Research Prospectus, at: http://www.birmingham.ac.uk/students/drp.aspx
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The School of Biosciences offers a number of UK Research Council (e.g. BBSRC, NERC) PhD studentships each year. Fully funded research council studentships are normally only available to UK nationals (or EU nationals resident in the UK) but part-funded studentships may be available to EU applicants resident outside of the UK. The deadline for applications is 6th January 2019.

Each year we also have a number of fully funded Darwin Trust Scholarships. These are provided by the Darwin Trust of Edinburgh and are for non-UK students wishing to undertake a PhD in the general area of Molecular Microbiology. The deadline for this scheme is also typically at the end of January each year.

Funding Notes

The project can be funded by the MIBTP-BBSRC training programme (UK and EU students; View Website) or a Darwin Trust scholarship (Worldwide). Please state in application which scheme you wish to be considered for. For MIBTP-BBSRC, you will need to fill in a University of Birmingham application AND the short notification form on the University of Warwick MIBTP portal. The notification form can be submitted here View Website

Further details on the BBSRC MIBTP scheme here: View Website
Deadline: early Jan 2021, please check the above link
Studentships available: 30
Stipend: RCUK standard rate (plus travel and laptop).

To check eligibility visit: View Website

References

1. Alekshun MN, Levy SB. (2007) Molecular mechanisms of antibacterial multidrug resistance. Cell. 128:1037-50.
2. Blair JM, Webber MA, Baylay AJ, Ogbolu DO, Piddock LJ. (2015) Molecular mechanisms of antibiotic resistance. Nat Rev Microbiol. 13:42-51.
3. Sharma P, Haycocks JRJ, Middlemiss AD, Kettles RA, Sellars LE, Ricci V, Piddock LJV, Grainger DC. (2017) The multiple antibiotic resistance operon of enteric bacteria controls DNA repair and outer membrane integrity. Nat Commun. 8:1444.


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