Aberdeen University Featured PhD Programmes
University of Oxford Featured PhD Programmes
Centre for Genomic Regulation (CRG) Featured PhD Programmes

Understanding neurovascular coupling and its importance in the interpretation of modern neuroimaging techniques


Department of Psychology

About the Project

During the past two decades, blood oxygenation level dependent (BOLD) functional magnetic resonance imaging (fMRI) has become the scientific technique of choice for investigating human brain function in the field of cognitive neuroscience. It exploits the local alterations in blood flow produced by changes in neural activity, termed neurovascular coupling. However, BOLD fMRI does not measure neural activity directly and hence a fundamental problem exists: how to interpret BOLD signal changes and make inferences about the neural activity that generates them. This is far from straightforward because the mechanisms linking events that produce neural changes to BOLD signaling are highly complex. For example, increased BOLD activity in a vast range of tasks and experimental conditions is interpreted as indicating areas of increased neural activity. However, many neural circuits in the brain are inhibitory and little is known about what corresponding fMRI signals are generated. Would an inhibitory neural signal be expected to generated negative BOLD for example? Consequently, multi-modal experiments that directly compare different indicators of hemodynamic activity and electrophysiological measures of neural signals are necessary if BOLD contrast is to be correctly interpreted.

Funding Notes

Self funded or externally sponsored students only. Intakes are usually October and March annually.

NB The University has some scholarships under competition each year. More details can be found - View Website

Email Now

Insert previous message below for editing? 
You haven’t included a message. Providing a specific message means universities will take your enquiry more seriously and helps them provide the information you need.
Why not add a message here

The information you submit to University of Sheffield will only be used by them or their data partners to deal with your enquiry, according to their privacy notice. For more information on how we use and store your data, please read our privacy statement.

* required field

Your enquiry has been emailed successfully



Search Suggestions

Search Suggestions

Based on your current searches we recommend the following search filters.



FindAPhD. Copyright 2005-2020
All rights reserved.