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Understanding of the Effect of Impurities in the Crystallisation of Pharmaceutical Polymorphs

  • Full or part time
  • Application Deadline
    Wednesday, May 01, 2019
  • Funded PhD Project (European/UK Students Only)
    Funded PhD Project (European/UK Students Only)

Project Description

This project is being pursued in collaboration with AstraZeneca and the successful applicant will be part of a larger research group supervised by Dr. Cruz-Cabeza, Dr. Vetter and Prof. Davey.

Polymorphism is the ability exhibited by organic molecules to crystallise in more than one structure. There has been considerable interest in this phenomenon in the last 20 years or so, especially because of the impact it has in solid form development of pharmaceuticals. This project will attempt to understand the effect of impurities on the crystallisation of pharmaceuticals with a special view on polymorphism.

The successful student will be expected to carry out experiments, primarily, but also do some computations and database analyses. Experimental techniques that the student will need to learn include: X-ray diffraction, calorimetry, various crystallisation techniques and also various types of microscopy.

Applicants should have or expect to achieve at least a 2.1 honours degree in Chemistry, Chemical Engineering or Physics.

Funding Notes

UK or EU students
Funding is available directly for this project.

iCASE Award – AstraZeneca + EPSRC

Related Subjects

How good is research at University of Manchester in Aeronautical, Mechanical, Chemical and Manufacturing Engineering?
Chemical Engineering

FTE Category A staff submitted: 33.90

Research output data provided by the Research Excellence Framework (REF)

Click here to see the results for all UK universities

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