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Understanding the biology of TEX12 as a centrosomal protein

  • Full or part time
  • Application Deadline
    Friday, January 11, 2019
  • Funded PhD Project (European/UK Students Only)
    Funded PhD Project (European/UK Students Only)

Project Description

All cells have to divide to ensure the survival of the organism. There are two main types of cellular division, meiosis and mitosis. For reproduction, cells divide through a specialised process called meiosis which produces cells with half the genetic material. Somatic cells divide by mitosis, where genetic material is maintained at a double copy level and two daughter cells are produced. In mitosis centrosomes play a critical role in organising microtubules and providing polarity required for cellular division. It was previously believed that meiosis differs from mitosis in that centrosomes dissipate in prophase of meiosis in mouse oocytes accompanied by the loss of centrioles and formation of multiple pericentriolar material-containing microtubule organising centres that are involved in spindle assembly instead.

However, recent studies reported that centriole remnants persist in fully grown oocytes. Similarly, we identified centrin-rich clusters at all stages of the meiotic oocyte division. This question is of critical importance as presence of centrosome-like structures in meiosis would not only change our understanding of this process but would also help us understand how first mitotic centrosomes are created. We have identified a novel protein, previously believed to be exclusively meiotic, to be present in both centrosome-like structures in meiosis but also in mitotic centrosomes. This PhD will focus on defining this novel observation and determining the role of meiotic centrin rich bodies in development.

For further information see the website:

To apply

Please complete the online application form and attach a full CV and covering letter. Informal enquiries may be made to

Funding Notes

This is a 4 year BBSRC studentship under the Newcastle-Liverpool-Durham DTP. The successful applicant will receive research costs, tuition fees and stipend (£14,777 for 2018-19). The PhD will start in October 2019. Applicants should have, or be expecting to receive, a 2.1 Hons degree (or equivalent) in a relevant subject. EU candidates must have been resident in the UK for 3 years in order to receive full support. There are 2 stages to the application process.


Salmon LJ, Sandhu S, Pastok MW, Wilson CL, Hunter JE, Perkins ND, Jennings C, Hunter N, Davies OR, McClurg UL (2019) Meiotic TEX12 is a novel centrosomal protein controlling fidelity of chromosome division in cancer cell. Manuscript submitted.

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