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Understanding the development of Industrial Streptomyces strain lineages


Project Description

Project Description: (Max 2000 characters including spaces)

A studentship is offered to undertake exciting research for a PhD degree. The studentship is a 4-year fully funded studentship awarded by the the IBioIC/BBSRC Collaborative Training Partnership. Clavulanic acid (CA) is a beta-lactamase inhibitor that is coformulated with Amoxicillin to help treat resistant bacterial infections. CA is produced naturally by the filamentous bacterium Streptomyces. CA is currently made industrially via fermentation using a Streptomyces strain that has been through successive rounds mutagenesis to improve CA production. The proposed work aims to use genome sequencing, comparative genomics and molecular genetics to identify key mutations that have enhanced CA production and study their effects on the bacterium.
You will work within the Microbiology and Industrial Biotechnology Group at the Strathclyde Institute of Pharmacy and Biomedical Sciences at the University of Strathclyde, where you will be given full training in bacterial molecular genetics, protein expression, protein biochemistry and bioinformatics. The Hoskisson Research group at Strathclyde is located in a purpose built, £35 million research building in the heart of Glasgow.

Funding Notes

IBioIC/BBSRC Collaborative Training Partnership

References

Hoskisson, P. A. & Fernández-Martínez, L.T (2018). Regulation of specialised metabolites in Actinobacteria - Expanding the paradigms. Environmental Microbiology Reports 10, 231-238.

Schniete, J. K., Cruz-Morales, P., Selem, N., Fernández-Martínez, L.T., Hunter, I. S., Barona-Gómez, F., & Hoskisson, P. A. (2018). Expanding primary metabolism helps generate the metabolic robustness to facilitate antibiotic biosynthesis in Streptomyces. mBio 9, e02283-17.

McClean, T., Hoskisson, P. A., & Seipke, R. F. (2016). Coordinate regulation of antimycin and candicidin
biosynthesis. mSphere, 1, e00305-16.

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