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Understanding the homeostatic response to DNA repair inhibitors in breast cancer


PhD Programmes

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Dr C Lord , Prof Andrew Tutt No more applications being accepted Funded PhD Project (Students Worldwide)

About the Project

For details on how to apply using our online recruitment system please see http://icr.ac.uk/phds.

The Institute of Cancer Research, London, is one of the world’s most influential cancer research institutes. We are committed to attracting and developing the best minds in the world to join us in our mission—to make the discoveries that defeat cancer.

Understanding the homeostatic response to DNA repair inhibitors in breast cancer

Project Description:
This project is aimed at understanding why some patients with breast cancer respond well to new targeted anti-cancer agents, such as PARP inhibitors, whilst others do not. Using novel models of breast cancer, we aim to assess how the evolution of breast cancers influences how cancers respond to PARP inhibitors and platinum salts, both of which are now used in the treatment of breast cancer.
The successful PhD candidate will use a variety of techniques and approaches to learn how breast cancers evolve when treated with PARP inhibitors or platinum salts. These will include the use of near-patient in vitro models of breast cancer, cancer genomics, functional genomics (including the use of high-throughput CRISPR-Cas9 genetic perturbation screens), biostatistics and cell biology. By the end of the PhD training programme, the PhD candidate will have skills in each of these approaches and will have generated data that will be used to interpret the results from clinical trials we are currently undertaking to understand PARP inhibitor and platinum salt responses. As such, this project has the potential to influence how patients with breast cancer and better treated.
Keywords /Subject Areas:

Cancer Therapy
Cancer Drug Resistance
PARP inhibitors
Breast Cancer
Quantitative biology
Bioinformatics
Statistics
Clinical Trials

Funding Notes

Students receive an annual stipend, currently £21,000 per annum, as well as having tuition fees (both UK/EU and overseas) and project costs paid for the four-year duration. We are open to applications from any eligible candidates and are committed to attracting and developing the best minds in the world.

For details on how to apply using our online recruitment system please see http://icr.ac.uk/phds. Please note we only accept applications via the online application system.

Candidates must have a first class or upper second class honours BSc Honours/MSc in Biology, Biochemistry or Chemistry.
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