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  Understanding the link between EBV and Multiple Sclerosis


   Institute for Molecular Bioscience

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  Prof Denise Doolan  Applications accepted all year round  Funded PhD Project (Students Worldwide)

About the Project

An opportunity exists for a PhD position in molecular immunology, where cutting-edge technologies will be applied to understand the molecular basis of the link between EBV and Multiple Sclerosis. Epstein-Barr virus (EBV) is the top identified causative agent of Multiple Sclerosis, but how this occurs is not known. This project aims to apply an innovative approach using proteome-wide screening of EBV to identify the subset of EBV proteins from the complete EBV proteome that triggers MS. It will compare responses in individuals with different stages of MS and apply sophisticated computational analytics to identify specific EBV proteins that predict MS disease. This EBV signature of MS could be translated into a clinic-friendly point-of-care test. If successful, this project could revolutionize the diagnosis and management of MS, providing patients with a quicker and more accurate diagnosis and enhanced quality of life.

 Subject areas:

Immunology, Molecular immunology, Systems biology, Multiple Sclerosis, Autoimmunity, EBV

Eligibility:

Entry: Bachelor degree with Honours Class I (or equivalent via outstanding record of professional or research achievements)

Experience/Background: laboratory-based experience in immunology, host-pathogen interactions, immune regulation and infectious diseases; excellent computer, communication, and organisational skills are required.

Biological Sciences (4)
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 About the Project