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Understanding the mechanism of action of ferro-nucleobase analogues

  • Full or part time
  • Application Deadline
    Applications accepted all year round
  • Self-Funded PhD Students Only
    Self-Funded PhD Students Only

Project Description

Through collaboration with Professor Jim Tucker (School of Chemistry) we are studying the cellular effects of a novel DNA base analogues based on the organometallic compound ferrocene. We have already shown that they are active in many cancer cell lines with a potency comparable to existing anti-cancer drugs like cisplatin and mechanistic work indicates that the mechanism of action is related to inhibition of DNA-synthesis in cells. The aim of this current project is to further understand the molecular mechanism of action of these agents. The project is biochemistry/cell biology-based although some experience of organic chemistry would be useful.

Techniques you will learn:

Cell culture including culture of 3D-spheroids
Cell viability assays
Molecular biology techniques including western blotting and PCR
Flow cytometry
Confocal microscopy

Funding Notes

Currently this position is only open to self-funded students and we will consider good applicants from anywhere in the world with a background in either chemistry or biochemistry with a minimum 2.1 degree. We are actively seeking funding and so funded positions may be available in the future

References

Jonathan L. Kedge Huy V. Nguyen Zahra Khan Louise Male Media K. Ismail, Holly V. Roberts, Nikolas J. Hodges Sarah L. Horswell Organometallic Nucleoside Analogues: Effect of Hydroxyalkyl Linker Length on Cancer Cell Line ToxicityFirst published: 17 October 2016 https://doi.org/10.1002/ejic.201600853

Huy V. Nguyen, Antoine Sallustrau†, Jan Balzarini, Matthew R. Bedford‡, John C. Eden, Niki Georgousi, Nikolas J. Hodges§, Jonathan Kedge, Youcef Mehellou∥, Chris Tselepis, and James H. R. Tucker. Organometallic Nucleoside Analogues with Ferrocenyl Linker Groups: Synthesis and Cancer Cell Line Studies. J. Med. Chem., 2014, 57 (13), pp 5817–5822

How good is research at University of Birmingham in Biological Sciences?

FTE Category A staff submitted: 42.80

Research output data provided by the Research Excellence Framework (REF)

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