About the Project
The overarching theme of this PhD would be to further develop this exciting work, including investigation of the functional role of the myometrial phosphoproteins identified as being important for normal labour in human parturition, and to investigate further the identified signalling pathways.
Methods would include myo-bath studies of human myometrium and metabolomic analysis of maternal and cord blood.
2. Lopez Bernal A. Overview. Preterm labour: mechanisms and management. BMC Pregnancy Childbirth 2007;7 Suppl 1:S2. doi: 10.1186/1471-2393-7-s1-s2 [published Online First: 2007/06/19]
3. Sharp GC, Hutchinson JL, Hibbert N, et al. Transcription Analysis of the Myometrium of Labouring and Non-Labouring Women. PloS one 2016;11(5):e0155413-e13. doi: 10.1371/journal.pone.0155413
4. Birchenall KA, Welsh GI, Lopez Bernal A. Metabolite Changes in Maternal and Fetal Plasma Following Spontaneous Labour at Term in Humans Using Untargeted Metabolomics Analysis: A Pilot Study. Int J Environ Res Public Health 2019;16(9) doi: 10.3390/ijerph16091527 [published Online First: 2019/05/06]
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